1,358 results found
    1. Neuroscience

    Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors

    Alessandro Papale et al.
    Two cell-penetrating peptides that inhibit Ras-ERK signalling and a potent clinically relevant MEK inhibitor block cocaine conditioned place preference and accelerate extinction of cocaine self-administration upon a single administration in mice.
    1. Neuroscience

    Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice

    Diptendu Mukherjee et al.
    The ventrolateral striatum is found to be recruited during the encoding of cocaine preference, within which Egr2-expressing ensembles are functionally important, as is the expression of Egr2 within them.
    1. Neuroscience

    Repeated social defeat stress enhances glutamatergic synaptic plasticity in the VTA and cocaine place conditioning

    Claire E Stelly et al.
    Enhanced glutamatergic synaptic plasticity in mesolimbic dopaminergic neurons may contribute to repeatedly stressed rats becoming more vulnerable to addiction.
    1. Neuroscience

    Extracting grid cell characteristics from place cell inputs using non-negative principal component analysis

    Yedidyah Dordek et al.
    Computational modeling of the brain’s navigation system reveals that place cells can drive the formation of hexagonal patterns experimentally observed in grid cells activity.
    1. Neuroscience

    Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing

    Hao Li et al.
    Rostromedial tegmental neurons encode motivational valence and opponent responses across a wide range of affective stimulus modalities, while also driving dopamine inhibition and conditioned place aversion to aversive stimuli.
    1. Neuroscience

    Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward

    Zhijian Zhang et al.
    The VTA-mOT DAergic pathway mediates a variety of naturalistic reward processes and different types of preferences including odor-preference.
    1. Neuroscience

    Stimulus-dependent relationships between behavioral choice and sensory neural responses

    Daniel Chicharro et al.
    New stimulus-dependencies of choice-related signals in sensory neurons uncovered by new analytical results and methods.
    1. Neuroscience

    Neural mechanisms of economic choices in mice

    Masaru Kuwabara et al.
    Inactivation of the lateral orbital area disrupts economic choice behavior and neurons in this area encode the value of offered and chosen options.
    1. Medicine
    2. Neuroscience

    High performance communication by people with paralysis using an intracortical brain-computer interface

    Chethan Pandarinath et al.
    New computer algorithms have allowed people with paralysis to achieve the highest reported typing performance using a brain-computer interface.
    1. Neuroscience

    NeuroQuery, comprehensive meta-analysis of human brain mapping

    Jérôme Dockès et al.
    Full-text analysis of the human brain-imaging literature can predict the spatial distribution of observations in the brain given the description of a subject of study.

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