184 results found
    1. Developmental Biology
    2. Neuroscience

    Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space

    Travis A Babola et al.
    Supporting cells in the cochlea change their shape in response to purinergic receptor activation, which influences hair cell excitability by altering potassium redistribution in the extracellular space.
    1. Neuroscience
    2. Physics of Living Systems

    Stiffness and tension gradients of the hair cell’s tip-link complex in the mammalian cochlea

    Mélanie Tobin et al.
    The tip-link complex of the hair cell is mechanically tuned along the tonotopic axis of the cochlea.
    1. Neuroscience

    Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae

    Wenxuan He et al.
    Heterodyne low-coherence interferometry demonstrates that the latency of the sound-induced reticular lamina vibration is significantly greater than that of the basilar membrane vibration in living gerbil cochleae.
    1. Developmental Biology
    2. Neuroscience

    A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea

    Meenakshi Prajapati-DiNubila et al.
    Opposing gradients of activin A and follistatin within the spiral shaped mammalian cochlea instruct the graded pattern of mechano-sensory hair cell formation.
    1. Developmental Biology
    2. Neuroscience

    Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling

    Sung-Ho Huh et al.
    Otic epithelial Fibroblast Growth Factors control the number of cochlear sensory progenitor cells through an FGF responsive periotic mesenchyme.
    1. Neuroscience

    Across-species differences in pitch perception are consistent with differences in cochlear filtering

    Kerry MM Walker et al.
    Humans and other animals have different strategies for extracting the pitch of sounds, potentially driven by the species-specific frequency selectivity of the ear.
    1. Neuroscience

    Microsecond interaural time difference discrimination restored by cochlear implants after neonatal deafness

    Nicole Rosskothen-Kuhl et al.
    Early deaf human CI users are often insensitive to sub-millisecond interaural time differences (ITDs); however, with synchronized CIs, early deafened rats learned to lateralize small ITDs near 50 µs.
    1. Developmental Biology
    2. Neuroscience

    Comprehensive transcriptome analysis of cochlear spiral ganglion neurons at multiple ages

    Chao Li et al.
    RNA-Seq analysis and in vivo validation via genetic approach uncover that Scrt2 and Celf4 are expressed in inner ear auditory neurons throughout development.
    1. Neuroscience

    Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus

    Tenzin Ngodup et al.
    A major new class of neuronal cell type has been discovered in the auditory system, having features that make it a critical component of auditory processing.
    1. Neuroscience

    The role of cochlear place coding in the perception of frequency modulation

    Kelly L Whiteford et al.
    Human perceptual sensitivity to frequency modulation across the hearing range can be explained by a unitary neural code based on neural responses to amplitude modulation and fidelity of cochlear tuning.

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