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    1. Developmental Biology
    2. Neuroscience

    A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea

    Meenakshi Prajapati-DiNubila et al.
    Opposing gradients of activin A and follistatin within the spiral shaped mammalian cochlea instruct the graded pattern of mechano-sensory hair cell formation.
    1. Developmental Biology
    2. Neuroscience

    Comprehensive transcriptome analysis of cochlear spiral ganglion neurons at multiple ages

    Chao Li et al.
    RNA-Seq analysis and in vivo validation via genetic approach uncover that Scrt2 and Celf4 are expressed in inner ear auditory neurons throughout development.
    1. Neuroscience

    Microsecond interaural time difference discrimination restored by cochlear implants after neonatal deafness

    Nicole Rosskothen-Kuhl et al.
    Early deaf human CI users are often insensitive to sub-millisecond interaural time differences (ITDs); however, with synchronized CIs, early deafened rats learned to lateralize small ITDs near 50 µs.
    1. Neuroscience

    The role of cochlear place coding in the perception of frequency modulation

    Kelly L Whiteford et al.
    Human perceptual sensitivity to frequency modulation across the hearing range can be explained by a unitary neural code based on neural responses to amplitude modulation and fidelity of cochlear tuning.
    1. Neuroscience

    Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma

    Guoqiang Wan et al.
    Overexpression of the growth factor neurotrophin-3 helps to repair noise-induced damage in the mouse inner ear by promoting the regeneration of damaged synapses.
    1. Developmental Biology

    Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis

    Mamoru Ishii et al.
    Live-cell imaging and mathematical modeling reveal the physical basis of collective cell migration underlying spiral cochlear duct formation during murine inner ear development.
    1. Neuroscience

    The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells

    Christopher L Cunningham et al.
    Murine TOMT is essential for transport of mechanotransduction components to stereocilia in cochlear hair cells.
    1. Neuroscience

    Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

    Adelaida M Celaya et al.
    Mitogen-activated protein kinase phosphatase 1 (DUSP1) deficiency causes early redox imbalance and increased inflammatory response in the cochlea, leading to cell loss and progressive neurosensory hearing loss.
    1. Cell Biology
    2. Developmental Biology

    Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates

    Martin L Basch et al.
    The cochlea deploys two Fringe proteins at exactly the same time and position to regulate a novel mode of Notch signaling that sets the boundary of the organ of Corti, the ear's hearing organ.
    1. Neuroscience
    2. Physics of Living Systems

    The frequency limit of outer hair cell motility measured in vivo

    Anna Vavakou et al.
    The cells in our inner ear commonly believed to provide fast mechanical feedback are too sluggish to follow the vibrations evoked by high-frequency sounds.