67 results found
    1. Cell Biology
    2. Developmental Biology

    Flattop regulates basal body docking and positioning in mono- and multiciliated cells

    Moritz Gegg, Anika Böttcher ... Heiko Lickert
    In cell types that acquire planar cell polarity, the protein Flattop regulates basal body docking and positioning.
    1. Neuroscience

    Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network

    Yu-Chen Chen, Xiaowei Li ... Gao-Jun Teng
    A comprehensive battery of behavioral, electrophysiological and functional MRI techniques has allowed the development of a data-driven conceptual model of the tinnitus-hyperacusis network.
    1. Cell Biology
    2. Neuroscience

    The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing

    Qing Fang, Artur A Indzhykulian ... Jonathan E Bird
    Two myosin 15 isoforms are required separately for the development and long-term maintenance of hearing.
    1. Cell Biology
    2. Neuroscience

    A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

    Philippe FY Vincent, Yohan Bouleau ... Didier Dulon
    A synaptic F-actin network tightly controls the flow of synaptic vesicles during exocytosis at the inner hair cell ribbons.
    1. Neuroscience

    Membrane properties specialize mammalian inner hair cells for frequency or intensity encoding

    Stuart L Johnson
    Mammalian primary sensory inner hair cells play an active role in auditory information processing, such that they show a preference for either timing or intensity coding.
    1. Neuroscience

    Perception as a closed-loop convergence process

    Ehud Ahissar, Eldad Assa
    Perception is proposed to be a dynamic motor-sensory closed-loop process in which information flows through the environment and the brain in continuous loops, converging towards steady-state percepts.
    1. Neuroscience

    Lognormal firing rate distribution reveals prominent fluctuation–driven regime in spinal motor networks

    Peter C Petersen, Rune W Berg
    Neuronal participation in generation of motor patterns in the spinal circuits is lognormal, which is an indication of a rich diversity of activity within the mean-driven as well as the fluctuation-driven regimes.
    1. Cell Biology
    2. Developmental Biology

    Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates

    Martin L Basch, Rogers M Brown II ... Andrew K Groves
    The cochlea deploys two Fringe proteins at exactly the same time and position to regulate a novel mode of Notch signaling that sets the boundary of the organ of Corti, the ear's hearing organ.
    1. Neuroscience

    Fast-spiking GABA circuit dynamics in the auditory cortex predict recovery of sensory processing following peripheral nerve damage

    Jennifer Resnik, Daniel B Polley
    Dynamic regulation of feedforward inhibition from parvalbumin-expressing inhibitory neurons is linked to the gradual restoration of cortical sensory processing following auditory nerve damage.
    1. Developmental Biology
    2. Neuroscience

    Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells

    Tao Jiang, Katie Kindt, Doris K Wu
    Emx2 reverses hair bundle orientation in sensory hair cells.

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