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    1. Developmental Biology

    Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy

    Meet K Patel, Warlen Piedade, Jakub K Famulski
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Mapping the transcriptional diversity of genetically and anatomically defined cell populations in the mouse brain

    Ken Sugino, Erin Clark ... Sacha B Nelson
    A transcriptome dataset of nearly 200 genetically identified mouse neuronal cell types revealed that short low-noise homeobox transcription factors and long neuronal effector genes best distinguish neuronal cell types.
    1. Neuroscience

    Synaptic mechanisms of top-down control in the non-lemniscal inferior colliculus

    Hannah M Oberle, Alexander N Ford ... Pierre F Apostolides
    Optogenetic and electrophysiological experiments show how a behaviorally relevant 'feedback' pathway from auditory cortex controls neural activity in the inferior colliculus, an auditory midbrain region important for processing complex time-varying sounds such as speech.
    1. Developmental Biology
    2. Neuroscience

    Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body

    Najia A Elkahlah, Jackson A Rogow ... E Josephine Clowney
    Sensory innervation density in the insect associative learning center is set by postsynaptic cells and accomplished by flexible allocation of processes by presynaptic cells.
    1. Neuroscience

    Resonating neurons stabilize heterogeneous grid-cell networks

    Divyansh Mittal, Rishikesh Narayanan
    Intrinsic neuronal resonance stabilizes heterogeneous neural networks by suppressing low-frequency perturbations.
    1. Neuroscience

    Generalization of learned responses in the mormyrid electrosensory lobe

    Conor Dempsey, LF Abbott, Nathaniel B Sawtell
    In vivo recordings and computational modeling of the electrosensory lobe of mormyrid fish provide a circuit-level description of how learning generalizes to new situations.
    1. Neuroscience

    Emergence and function of cortical offset responses in sound termination detection

    Magdalena Solyga, Tania Rinaldi Barkat
    Cortical offset responses are not only inherited from the periphery but also amplified and de novo generated, and preventing them decreases the ability to detect sound termination.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Stable population structure in Europe since the Iron Age, despite high mobility

    Margaret L Antonio, Clemens L Weiß ... Jonathan K Pritchard
    Reconstructing human mobility patterns using historical period genomes illustrates how the Roman Empire’s military and economic activities catalyzed an era of transient movement against the backdrop of generations-long prehistoric migrations.
    1. Neuroscience

    Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

    Timothy Erickson, Clive P Morgan ... Teresa Nicolson
    A zebrafish model for a particular form of human deafness (DFNB63) changes our view of this disease by revealing a defect in the localization of Transmembrane channel-like proteins that are essential for mechanotransduction in sensory cells.
    1. Cell Biology
    2. Neuroscience

    A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

    Philippe FY Vincent, Yohan Bouleau ... Didier Dulon
    A synaptic F-actin network tightly controls the flow of synaptic vesicles during exocytosis at the inner hair cell ribbons.