ENU mutagenesis in pigs is an efficient strategy to introduce mutations at the whole-genome level and mutants have been generated on a large scale for agricultural production and biomedical research.
Simon Nimpf, Erich Pascal Malkemper ... David A Keays
Cuticulosomes are organelles found in the hair cells of birds that are composed of ferritin nanoparticles, form rapidly after hatching by the fusion of vesicular structures, and may play an indirect role in magnetic sensation.
An extracellular modulator of IGF1 signaling, Pappaa, regulates endoplasmic reticulum–mitochondria connections, which are critical for metabolic homeostasis and hair cell survival.
Disruption of epoxide hydrolysis inducing oxidative stress and cellular senescence is a novel mechanism responsible for lipoatrophic monogenic diabetes.
Maria-Daniela Cirnaru, Sicheng Song ... Michelle E Ehrlich
RNAseq and ATACseq are utilized to identify transcription factors participating in striatal compartmentation into striosome and matrix, and roles for Stat1, Olig2, and Foxf2 are validated in vitro and in vivo.