5,795 results found
    1. Genetics and Genomics

    Neurodevelopmental Disorders: Beyond protein-coding genes

    Anna Lozano-Ureña, Sacri R Ferrón
    A long non-coding RNA called lnc-NR2F1 regulates several neuronal genes, including some involved in autism and intellectual disabilities.
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    1. Genetics and Genomics

    Codon optimization underpins generalist parasitism in fungi

    Thomas Badet et al.
    Codon optimization through biased synonymous substitutions is a characteristic feature of the genomes of generalist fungal parasites and is associated with the colonization of multiple hosts.
    1. Neuroscience

    Feedback optimizes neural coding and perception of natural stimuli

    Chengjie G Huang et al.
    Neurophysiological and behavioral approaches reveal how coordinated input from descending pathways shapes the tuning properties of electrosensory neurons in order to optimize coding of natural stimuli through temporal whitening.
    1. Neuroscience

    Multiplexed coding by cerebellar Purkinje neurons

    Sungho Hong et al.
    Cerebellar Purkinje neurons use a multiplexed simple spike code combining synchrony/spike time and firing rate, with each component encoding distinct information about movements such as motion onset timing and kinematics.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    C-mannosylation supports folding and enhances stability of thrombospondin repeats

    Aleksandra Shcherbakova et al.
    C-mannosylation supports native folding of thrombospondin type 1 repeats in the endoplasmic reticulum and stabilizes the folded proteins by modulating the dynamics of the tryptophan-arginine ladder.
    1. Developmental Biology
    2. Immunology and Inflammation

    Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus

    Federico Andrea Moretti et al.
    T cell progenitor homing into the thymus requires kindlin-3 to stabilize their adhesion to vascular integrin ligands when blood flow velocities and shear rates increase during development.
    1. Neuroscience

    Stimulus background influences phase invariant coding by correlated neural activity

    Michael G Metzen, Maurice J Chacron
    Building on previous work (Metzen et al., 2016), a combination of neurophysiological and behavioral approaches reveals that changes in the background strongly impacts invariant coding and perception of behaviourally relevant signals.
    1. Cell Biology

    Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

    Satoshi Tsunoda et al.
    Adapting a cytosolic enzyme that breaks down glutathione to function in the lumen of the endoplasmic reticulum challenges the long-held view that reduced glutathione fuels disulfide rearrangements during protein folding.
    1. Microbiology and Infectious Disease

    RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies

    Fiona Tulloch et al.
    Attenuating candidate live virus vaccines by incorporating unfavoured codon pairs to reduce translation efficiency is actually mediated though changes in frequencies of CpG and UpA dinucleotides, which make viruses more visible to the innate immune system.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Codon choice directs constitutive mRNA levels in trypanosomes

    Janaina de Freitas Nascimento et al.
    The information for mRNAs expression level is set by codon choice in trypanosomes and requires translation to be interpreted into a turnover rate.

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