Neurophysiological and behavioral approaches reveal how coordinated input from descending pathways shapes the tuning properties of electrosensory neurons in order to optimize coding of natural stimuli through temporal whitening.
Cerebellar Purkinje neurons use a multiplexed simple spike code combining synchrony/spike time and firing rate, with each component encoding distinct information about movements such as motion onset timing and kinematics.
Building on previous work (Metzen et al., 2016), a combination of neurophysiological and behavioral approaches reveals that changes in the background strongly impacts invariant coding and perception of behaviourally relevant signals.
Adapting a cytosolic enzyme that breaks down glutathione to function in the lumen of the endoplasmic reticulum challenges the long-held view that reduced glutathione fuels disulfide rearrangements during protein folding.
Attenuating candidate live virus vaccines by incorporating unfavoured codon pairs to reduce translation efficiency is actually mediated though changes in frequencies of CpG and UpA dinucleotides, which make viruses more visible to the innate immune system.