6,904 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Tracing a protein’s folding pathway over evolutionary time using ancestral sequence reconstruction and hydrogen exchange

    Shion An Lim et al.
    Pulsed-labeling hydrogen exchange on the ribonuclease H family show that the major folding intermediate is conserved over three billion years of evolution, but the path leading to this intermediate varies.
    1. Neuroscience

    Independent theta phase coding accounts for CA1 population sequences and enables flexible remapping

    Angus Chadwick et al.
    Independent coding without synaptic coordination explains complex sequences of population activity observed during theta states and maximizes the number of distinct environments that can be encoded through population theta sequences.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    mRNA-programmed translation pauses in the targeting of E. coli membrane proteins

    Nir Fluman et al.
    Translation pauses occur in strategic positions to facilitate the production of properly folded membrane proteins in bacteria.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function

    Simon Weinberger et al.
    The coding sequences of a very highly conserved family of neurogenic transcription factors from different species have evolved to generate proteins that have different life times causing them to display quantitatively different neural induction potentials.
    1. Plant Biology

    Natural haplotypes of FLM non-coding sequences fine-tune flowering time in ambient spring temperatures in Arabidopsis

    Ulrich Lutz et al.
    Gene expression changes associated with polymorphisms in non-coding sequences of the flowering time regulator FLM directly influence flowering time in ambient temperature in Arabidopsis over an extended vegetative period.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Protein-mediated RNA folding governs sequence-specific interactions between rotavirus genome segments

    Alexander Borodavka et al.
    In rotaviruses, the selective packaging of eleven distinct genomic RNA segments requires virus-encoded protein NSP2 to alter the RNA structures, facilitating their interactions with each other.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A de novo evolved gene in the house mouse regulates female pregnancy cycles

    Chen Xie et al.
    A female specifically expressed new protein-coding gene that has emerged out of non-coding sequences without detectable signatures of adaptive evolution affects female pregnancy cycles.
    1. Biochemistry and Chemical Biology

    Ribosomes slide on lysine-encoding homopolymeric A stretches

    Kristin S Koutmou et al.
    Ribosomes undergo an unanticipated movement (‘sliding’) while translating homopolymeric A sequences, which provides a biochemical rationale for the observation that iterated AAA codons are under-represented in gene-coding sequences.
    1. Chromosomes and Gene Expression

    Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides

    Jamie R Wangen, Rachel Green
    Ribosome profiling reveals genome-wide stimulation of stop codon readthrough by aminoglycosides that is influenced sequence context.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility

    Mehdi Goudarzi et al.
    Defining the biological functions of long non-coding RNAs, individually or as a class, and teasing apart the role of underlying genomic sequences remains the biggest challenge for this field.

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