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    1. Neuroscience

    Learning multiple variable-speed sequences in striatum via cortical tutoring

    James M Murray, G Sean Escola
    Inspired by the sparse, sequential neural activity patterns observed in striatum, a new circuit model implements variable-speed activity, the encoding of multiple sequences, and a tutor/student relationship between cortex and striatum.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins

    Sondos Samandi et al.
    Conventional annotations of coding sequences have missed thousands of short open-reading frames encoding proteins that are conserved and with specific functions.
    1. Microbiology and Infectious Disease

    Codon usage bias controls mRNA and protein abundance in trypanosomatids

    Laura Jeacock et al.
    Global relative mRNA and protein abundance in trypanosomatids can be effectively estimated at transcriptomic and proteomic scales based on protein-coding sequences alone.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Cytoskeleton: The mother of all actins?

    Felipe Merino, Stefan Raunser
    Insight
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    1. Evolutionary Biology

    Multicellularity: From brief encounters to lifelong unions

    Bradley JSC Olson
    Insight
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    1. Developmental Biology and Stem Cells

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.