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    1. Neuroscience

    A robust activity marking system for exploring active neuronal ensembles

    Andreas T Sørensen et al.
    A new system for tagging activated neuronal population offers multiple advantages over existing systems based on immediate early genes, including greater sensitivity and specificity, and suitability for easy application in species other than mice.
    1. Evolutionary Biology

    Rapid diversification associated with a macroevolutionary pulse of developmental plasticity

    Vladislav Susoy et al.
    Evolutionary novelty is promoted by a macroevolutionary pulse of developmental plasticity, but is enhanced by secondary fixation, which permits developmental character release and further morphological exploration.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

    Rebecca M Voorhees, Ramanujan S Hegde
    Structures of the signal recognition particle before and after it captures a transmembrane domain suggest how it chooses, engages, and shields its clients during membrane protein targeting to the endoplasmic reticulum.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

    Ali H Alghamdi et al.
    Study of TbAQP2 adaptations and substrate interactions shows how this aquaglyceroporin enables cellular entry of large antimicrobial agents in Trypanosoma brucei.
    1. Immunology and Inflammation

    Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

    Ricardo A Fernandes et al.
    Surrogate agonist peptide ligands discovered through screening of an IAb-peptide library potentiate expansion of visceral adipose tissue resident regulatory T cells and protect mice from inflammation and improve metabolic indices.
    1. Chromosomes and Gene Expression

    GC content shapes mRNA storage and decay in human cells

    Maïté Courel et al.
    The GC content of human mRNAs is key to P-body localization and protein yield, and has a major impact on their post-transcriptional control.
    1. Biochemistry and Chemical Biology

    RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not

    Michael W Webster et al.
    Biochemical reconstitution of deadenylation and analysis of binding kinetics reveals how RNA-binding proteins select their mRNA targets.
    1. Computational and Systems Biology

    Inferring joint sequence-structural determinants of protein functional specificity

    Andrew F Neuwald et al.
    A statistical approach for predicting non-active site residues responsible for allostery, cooperativity, or other subtle but functionally important interactions is described and applied to various protein families.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Codon choice directs constitutive mRNA levels in trypanosomes

    Janaina de Freitas Nascimento et al.
    The information for mRNAs expression level is set by codon choice in trypanosomes and requires translation to be interpreted into a turnover rate.
    1. Biochemistry and Chemical Biology

    LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection

    Sandy Mattijssen et al.
    The messenger RNA encoding La-related protein-4 (LARP4) contains a short region of instability whose codon clusters are sensitive to low abundance tRNAs that when elevated increase LARP4 activity for poly(A) lengthening of ribosomal protein mRNAs and other mRNAs.