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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans

    Donato Giovannelli et al.
    The genome of Thermovibrio ammonificans encodes ancestral pathways (e.g., hydrogen oxidation) and more recently acquired ones (e.g., nitrate reduction) and a hybrid pathway for CO2 fixation.
    1. Neuroscience

    Regulation of two motor patterns enables the gradual adjustment of locomotion strategy in Caenorhabditis elegans

    Ingrid Hums et al.
    Peptidergic neurons regulate undulation and turning movements to enable Caenorhabditis elegans to gradually adjust its locomotion strategy from dispersal to local search.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Expression noise facilitates the evolution of gene regulation

    Luise Wolf et al.
    In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.
    1. Structural Biology and Molecular Biophysics

    Residue proximity information and protein model discrimination using saturation-suppressor mutagenesis

    Anusmita Sahoo et al.
    Experimental determination of residue contacts from mutational data allows model discrimination and identification of in vivo functional conformations of proteins.
    1. Cell Biology
    2. Immunology and Inflammation

    Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

    Roybel R Ramiscal et al.
    The ubiquitin ligase ROQUIN cross-talks with cellular metabolic signals to generate protective T cell-dependent antibody responses.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Real-time observation of signal recognition particle binding to actively translating ribosomes

    Thomas R Noriega et al.
    The signal recognition particle only stably engages translating ribosome nascent-chain complexes exposing a functional signal sequence.
    1. Biochemistry and Chemical Biology

    Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation

    Lu Lv et al.
    High-throughput phenotypic screening followed by unbiased target identification reveals a new molecular glue HQ461 that induces CDK12-DDB1 interaction to promote degradation of Cyclin K via the ubiquitin proteasome system.
    1. Developmental Biology

    An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes

    Nathan D Lawson et al.
    Computational efforts yield a zebrafish transcriptome annotation that provides more sensitive and comprehensive gene detection over existing annotations when used for bulk or single-cell RNA-seq.
    1. Developmental Biology
    2. Neuroscience

    Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration

    Chu Hsien Lim et al.
    An optogenetic approach has been developed to model Alzheimer's disease allowing light-induced Amyloid-β aggregation and tested in three model organisms, Drosophila, C. elegans and D. rerio.
    1. Cancer Biology
    2. Cell Biology

    Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy

    Xiaolei Li et al.
    Leukemia-Related Protein 16 (LRP16), a member of the macro domain family, plays a crucial role in orchestrating genotoxicity-initiated NF-κB signaling in the colon and the pathophysiological relevance of NF-κB activation induced by LRP16 in colonic cell survival/recovery from extrinsic DNA damage.