White matter microstructure alterations in key bundles affected in Alzheimer's disease are related to amyloid and tau pathology in the preclinical phase of sporadic and autosomal-dominant Alzheimer's disease.
Phasic microfilament behaviors of the growth and stabilization of cortical actin caps are driven by distinct combinations of actin regulatory proteins, which display features of a deep competition for G-actin.
Cross-species transcriptomic analysis and high-throughput behavioral assays in a Drosophila model of Huntington's disease show that downregulation of glial genes involved in synaptic function compensates for disease-related excitotoxicity.
Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
ImmunoCluster permits nonspecialist users to interrogate liquid and imaging mass, and flow cytometry datasets, resolving novel layers of cellular heterogeneity and insight, as well as producing publishable outputs and figures.