6,712 results found
    1. Neuroscience

    Forced choices reveal a trade-off between cognitive effort and physical pain

    Todd A Vogel et al.
    Cognitive effort is aversive and people will accept physical pain to avoid it, but this avoidance does not appear to share the same fundamental characteristics of pain avoidance.
    1. Neuroscience

    Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience

    Alexander Fengler et al.
    A novel method and software provides researchers with the capability to rapidly, flexibly, and robustly perform Bayesian parameter estimation of theoretically meaningful models in cognitive neuroscience that were heretofore intractable.
    1. Neuroscience

    Modulation of tonotopic ventral medial geniculate body is behaviorally relevant for speech recognition

    Paul Glad Mihai et al.
    Ultra-high field neuroimaging dissects the ventral medial geniculate body (vMGB) of the primary auditory pathway from other MGB subregions and reveals that vMGB top-down modulation is relevant for speech recognition.
    1. Neuroscience

    The expression of established cognitive brain states stabilizes with working memory development

    David Florentino Montez et al.
    The excessive behavioral variability associated with adolescence is the result of greater instability of widespread or global gain signals which produces greater variability in the amplitude of expression of whole-brain states of task-related activity.
    1. Medicine
    2. Neuroscience

    Recovery of consciousness and cognition after general anesthesia in humans

    George A Mashour et al.
    Cognitive reconstitution after pharmacologic unconsciousness is an extended process, executive function is more robust than expected, and the healthy human brain is resilient to the effects of deep general anesthesia.
    1. Neuroscience

    Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control

    Vinod Menon et al.
    In vivo quantitative analysis of multi-shell diffusion MRI reveals novel insights into microstructure of human insular cortex and its functional circuits associated with the salience network and cognitive control.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

    Franziska Bleichert et al.
    Electron microscopy uncovers the structure of the origin recognition complex (ORC) in metazoans, and reveals how mutations in the ORC6 subunit lead to Meier-Gorlin syndrome in humans.
    1. Chromosomes and Gene Expression

    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

    Hsiang-Chen Chou et al.
    The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.
    1. Structural Biology and Molecular Biophysics

    Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

    Xue Fei et al.
    Cryo-EM structures of the AAA+ ClpXP protease bound to an ssrA degron reveal the mechanism of substrate recognition and show how the machine transitions from recognition to translocation and unfolding.
    1. Neuroscience

    Efficient recognition of facial expressions does not require motor simulation

    Gilles Vannuscorps et al.
    It is possible to account for efficient facial expression recognition without having to invoke a mechanism of motor simulation, even in very sensitive and challenging tasks.

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