5,992 results found
    1. Immunology and Inflammation

    RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

    Kirsteen M Tullett et al.
    Dendritic cell recognition and processing of antigens from dead cells, utilising the Clec9A-damage recognition receptor, is controlled by a novel RNF41-ubiquitin-mediated regulatory pathway.
    1. Neuroscience

    Cascade of neural processing orchestrates cognitive control in human frontal cortex

    Hanlin Tang et al.
    A dynamic and hierarchical sequence of steps in human frontal cortex orchestrates cognitive control.
    1. Structural Biology and Molecular Biophysics

    Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

    Xue Fei et al.
    Cryo-EM structures of the AAA+ ClpXP protease bound to an ssrA degron reveal the mechanism of substrate recognition and show how the machine transitions from recognition to translocation and unfolding.
    1. Neuroscience

    Normal cognitive and social development require posterior cerebellar activity

    Aleksandra Badura et al.
    Social and cognitive functions require normal activity during development of the posterior cerebellum.
    1. Biochemistry and Chemical Biology

    Circularization restores signal recognition particle RNA functionality in Thermoproteus

    André Plagens et al.
    Archaea can contain permuted versions of the universal signal recognition particle RNA, which require a moonlighting activity of the tRNA splicing machinery to generate functional circular RNAs.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Real-time observation of signal recognition particle binding to actively translating ribosomes

    Thomas R Noriega et al.
    The signal recognition particle only stably engages translating ribosome nascent-chain complexes exposing a functional signal sequence.
    1. Neuroscience

    Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control

    Vinod Menon et al.
    In vivo quantitative analysis of multi-shell diffusion MRI reveals novel insights into microstructure of human insular cortex and its functional circuits associated with the salience network and cognitive control.
    1. Immunology and Inflammation

    The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition

    Fu-Lien Hsieh, Matthew K Higgins
    The structure of a human antibody in which the variable loops position a human protein LAIR1 for antigen recognition, reveals a novel and indirect mode of antibody function.
    1. Ecology
    2. Neuroscience

    Individual recognition and the ‘face inversion effect’ in medaka fish (Oryzias latipes)

    Mu-Yun Wang, Hideaki Takeuchi
    Medaka fish were able to use faces for individual recognition, and were slower to recognise inverted faces but not inverted non-face shapes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

    Franziska Bleichert et al.
    Electron microscopy uncovers the structure of the origin recognition complex (ORC) in metazoans, and reveals how mutations in the ORC6 subunit lead to Meier-Gorlin syndrome in humans.

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