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    1. Neuroscience

    Noradrenaline blockade specifically enhances metacognitive performance

    Tobias U Hauser, Micah Allen ... Raymond J Dolan
    The neurotransmitter noradrenaline selectively modulates metacognition, the conscious insight into one's performance, but does not alter perceptual decision making, revealing that different neuromodulators affect different stages of a decision making process.
    1. Computational and Systems Biology
    2. Neuroscience

    Bottom-up and top-down computations in word- and face-selective cortex

    Kendrick N Kay, Jason D Yeatman
    A computational model reveals how response properties of category-selective regions in the visual cortex reflect both bottom-up stimulus-driven signals and top-down attentional signals from the parietal cortex.
    1. Neuroscience

    Push-pull competition between bottom-up and top-down auditory attention to natural soundscapes

    Nicholas Huang, Mounya Elhilali
    Everyday soundscapes dynamically engage attention towards target sounds or salient ambient events, with both attentional forms engaging the same fronto-parietal network but in a push-pull competition for limited neural resources.
    1. Neuroscience

    Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function

    Surjeet Mastwal, Xinjian Li ... Kuan Hong Wang
    Frontal cortical circuit alterations and cognitive deficits identified in mouse genetic models are reversed by chemogenetic or optogenetic stimulation of the mesocortical dopamine circuit in an adolescent period.
    1. Neuroscience

    Anxiety dissociates the adaptive functions of sensory and motor response enhancements to social threats

    Marwa El Zein, Valentin Wyart, Julie Grèzes
    Social threats trigger enhanced neural representations within 200 milliseconds in sensory and motor systems of the human brain as a function of anxiety, highlighting its adaptive function in reacting rapidly to dangers in the environment.
    1. Neuroscience

    Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain

    Mohammad Ali Salehinejad, Elham Ghanavati ... Michael A Nitsche
    The sleep-deprived brain in humans undergoes upscaled intracortical excitability which diminishes induction of LTP-like plasticity via transcranial electrical stimulation while converting the LTD-like to LTP-like plasticity and these physiological changes couple with impaired learning, memory, and attention at behavioral level.
    1. Neuroscience

    Causal manipulation of functional connectivity in a specific neural pathway during behaviour and at rest

    Vanessa M Johnen, Franz-Xaver Neubert ... Matthew F S Rushworth
    Functional connectivity in the human brain reflects changes in synaptic plasticity induced with repeated paired stimulation.
    1. Neuroscience

    Elevating acetyl-CoA levels reduces aspects of brain aging

    Antonio Currais, Ling Huang ... Pamela Maher
    A novel neuroprotective pathway that enhances acetyl-CoA metabolism via inhibition of acetyl-CoA carboxylase 1 may prevent the contribution of the aging process in the brain to Alzheimer's disease.
    1. Neuroscience

    Neural evidence of functional compensation for fluid intelligence in healthy ageing

    Ethan Knights, Richard N Henson ... Kamen A Tsvetanov
    Older people can recruit additional brain regions to help perform complex tasks, possibly compensating for age-related changes in other parts of the brain.
    1. Neuroscience

    Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling

    Bob Bramson, Hanneke EM den Ouden ... Karin Roelofs
    Non-invasive manipulation of endogenously coupled neural rhythms enhances human control of social-emotional actions.