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    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons

    Pedro L Martinez-Espinosa, Jianping Wu ... Christopher J Lingle
    Sodium-activated potassium ion currents encoded by the kcnt1 gene delay action potential firing in DRG neurons by activity preceding an action potential.
    1. Neuroscience

    An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination

    Jason J Early, Katy LH Marshall-Phelps ... David A Lyons
    A fully automated high-resolution in vivo screening platform for zebrafish was implemented and used to identify novel compounds that regulate oligodendrocyte lineage progression.
    1. Neuroscience

    Mother brain is wired for social moments

    Ortal Shimon-Raz, Roy Salomon ... Ruth Feldman
    Mother brain shows special sensitivity to social moments of mother-infant synchrony, compared to other caregiving experiences, through enhanced activation across the caregiving network, response to oxytocin administration, and temporal consistency.
    1. Neuroscience

    Sub-cone visual resolution by active, adaptive sampling in the human foveola

    Jenny L Witten, Veronika Lukyanova, Wolf M Harmening
    High-resolution foveal imaging and micro-psychophysics reveal that the human oculomotor system finely adjusts drift motion of the eye in an acuity task to enhance retinal sampling, achieving sub-cell resolution.
    1. Neuroscience

    Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

    Carmen Capone, Fabrice Dabertrand ... Anne Joutel
    Extracellular matrix signaling constitutively regulates cerebral blood flow in both physiological and pathological settings.
    1. Developmental Biology
    2. Genetics and Genomics

    Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability

    Ignacy Czajewski, Bijayalaxmi Swain ... Daan MF van Aalten
    Modelling O-GlcNAc transferase intellectual disability reveals the roles of this post-translational modification in regulating normal axonal terminal morphology and maintaining appropriate sleep homeostasis, pharmacological and genetic rescues of O-GlcNAcylation highlight the complexities of addressing this disorder.
    1. Neuroscience

    Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making

    Stijn A Nuiten, Jan Willem de Gee ... Simon van Gaal
    Pharmacologically elevated catecholamine levels and spatial attention jointly shape perceptual decision-making, revealed by unique, similar, and interactive effects on behavior, drift diffusion modeling parameters, and electrophysiology.
    1. Neuroscience

    Suppression and facilitation of human neural responses

    Michael-Paul Schallmo, Alexander M Kale ... Scott O Murray
    Spatial suppression during motion perception reflects reduced neural response magnitudes in visual areas but is not primarily driven by neural inhibition.
    1. Cell Biology
    2. Developmental Biology

    Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

    Andrew Kodani, Timothy W Yu ... Jeremy F Reiter
    To control centriole duplication, centriolar satellite proteins assemble a microcephaly-associated protein complex at the centrosome and activate cyclin-dependent kinase 2.
    1. Epidemiology and Global Health

    Relationship between changing malaria burden and low birth weight in sub-Saharan Africa: A difference-in-differences study via a pair-of-pairs approach

    Siyu Heng, Wendy P O'Meara ... Dylan S Small
    A novel pair-of-pairs matching approach finds that community-level reductions in malaria burden can potentially substantially reduce the low birth weight rate in sub-Saharan Africa, particularly among firstborns.