Metabolic health and longevity can be separated by ovariectomy, which also protects female mice lacking hepatic mTORC2 from midlife mortality.

CaImAn is an open-software package that equips the neuroscience community with a set of turnkey, fast and scalable solutions to pre-processing problems arising in single cell calcium imaging data analysis.

Structures of a TMEM16 phospholipid scramblase reveal that its Ca²⁺-dependent activation entails global conformational changes and how these rearrangements affect the membrane to enable transbilayer lipid transfer.

Selective degradation of mature miRNAs shapes temporal miRNA expression patterns and is important for proper regulation of target genes to support normal development of Drosophila embryos.

Achieving autotrophy in E. coli by introducing a small number of genetic changes crosses a milestone in engineering major metabolic transitions and paves a way for sustainable bio-production from CO₂.

High resolution SthK channel cryo-EM structures in different ligand-bound states combined with single-channel functional data in the same conditions constrain a gating mechanism for CNG channels.

The technique of serial blockface scanning electron microscopy, which permits the complete reconstruction of neuronal structures, allows comparison of the detailed "wiring diagrams" of lateral-line receptor organs in wild-type and mutant zebrafish.

Stimulus-receptivity loss increases coupling of a sensory neuron to a second sensory circuit by upregulating neuropeptide receptors, enhancing output of the second circuit, and providing a mechanism for cross-modal plasticity.

A novel mutation in SCGN is associated with risk for inflammatory bowel disease and implicates the intestinal neuroendocrine compartment in the pathogenesis of this disorder.

Structural analysis reveals large-scale conformational changes in the active site metallocluster of a CO2-fixing enzyme.