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    1. Chromosomes and Gene Expression

    MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion

    Ge Zheng et al.
    Systematic analyses of DNA replication machinery components in human cells reveal a requirement of MCM-dependent de novo loading or mobilization of cohesin at replication forks in establishing sister-chromatid cohesion.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    CTCF and cohesin regulate chromatin loop stability with distinct dynamics

    Anders S Hansen et al.
    Single-molecule imaging of CTCF and cohesin in live cells suggests that chromatin loops are dynamic structures that frequently form and fall apart.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes

    Aaron F Severson, Barbara J Meyer
    Mechanisms that tether and release replicated sister chromatids to produce sperm and eggs rely extensively on meiotic cohesin complexes that are endowed with unexpectedly different properties specified by a single interchangeable subunit, the α-kleisin.
    1. Chromosomes and Gene Expression

    The CDK Pef1 and protein phosphatase 4 oppose each other for regulating cohesin binding to fission yeast chromosomes

    Adrien Birot et al.
    Cohesin loader activity is regulated by phosphorylation of its cohesin substrate.
    1. Chromosomes and Gene Expression

    Scc2/Nipbl hops between chromosomal cohesin rings after loading

    James Rhodes et al.
    The cohesin loading factor Scc2/Nipbl interacts frequently with cohesin after the loading reaction in a manner consistent with a role in stimulating loop extrusion.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structural evidence for Scc4-dependent localization of cohesin loading

    Stephen M Hinshaw et al.
    Cohesin loading at centromeres depends on a conserved surface cluster of amino-acid residues on the cohesin loading protein, Scc4.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

    Gordana Wutz et al.
    CTCF protects cohesinSTAG1 from WAPL.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Determining cellular CTCF and cohesin abundances to constrain 3D genome models

    Claudia Cattoglio et al.
    Absolute quantification of CTCF and cohesin reveals quantitative constraints on 3D genome organization and illuminates the molecular architecture of the cohesin complex.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner

    Stefan Golfier et al.
    Reconstitution of DNA loop extrusion in cellular contexts using Xenopus egg extracts shows that condensin extrudes DNA loops non-symmetrically in metaphase, whereas cohesin extrudes DNA loops symmetrically in interphase.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Cohesion is established during DNA replication utilising chromosome associated cohesin rings as well as those loaded de novo onto nascent DNAs

    Madhusudhan Srinivasan et al.
    Sister chromatid cohesion is established during replication by two independent pathways operating in parallel, one converts chromosomal cohesin into cohesive structures while the other loads cohesin onto nascent DNAs.