202 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae

    Wei Zhang et al.
    E3 ubiquitin ligase Bre1-induced H2B monoubiquitination is epigenetically important for recruiting replication factor Mcm10 and cohesion establishment factors Ctf4, Ctf18 and Eco1 to early replication origins to establish sister chromatid cohesion.
    1. Neuroscience

    LRRTM1 underlies synaptic convergence in visual thalamus

    Aboozar Monavarfeshani et al.
    The synaptic cell adhesion molecule, leucine-rich repeat transmembrane neuronal 1 (LRRTM1), plays an important role in the establishment of retinal convergence onto relay cells in mouse visual thalamus.
  1. Point of View: How should novelty be valued in science?

    Barak A Cohen
    An over-emphasis on novelty is having detrimental effects on science.
    1. Plant Biology

    Antimicrobial peptide expression in a wild tobacco plant reveals the limits of host-microbe-manipulations in the field

    Arne Weinhold et al.
    The attempt to manipulate a microbiome in planta to study the ecological consequences under field conditions leaves plants and their microbes surprisingly unimpressed.
    1. Developmental Biology
    2. Evolutionary Biology

    Germ layer-specific regulation of cell polarity and adhesion gives insight into the evolution of mesoderm

    Miguel Salinas-Saavedra et al.
    The expression of 'bilaterian-mesodermal’ genes changes the epithelial properties of the endomesoderm during the embryogenesis of the cnidarian Nematostella vectensis.
    1. Stem Cells and Regenerative Medicine
    2. Human Biology and Medicine

    Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

    Marko Z Nikolić et al.
    Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.
    1. Developmental Biology
    2. Neuroscience

    Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Camille Charoy et al.
    Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.
    1. Developmental Biology
    2. Neuroscience

    The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections

    Xiaojun Xie et al.
    The organization of layered/laminated axon projections in specific regions of the fruitfly central brain is regulated by short-range repulsive guidance and is critical for local inhibitory circuit formation and function.
    1. Ecology

    Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis

    John A Burns et al.
    The endosymbiosis between an alga and the spotted salamander shows several parallels to invertebrate-algal symbioses as well as to pathogen associations in vertebrate animals.
    1. Chromosomes and Gene Expression

    Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis

    Candice L Wike et al.
    A histone modification that alters the nucleosome structure occurs in mitosis and promotes chromosome packaging and the timely removal of condensin I and cohesion, to achieve chromosome segregation.

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