E3 ubiquitin ligase Bre1-induced H2B monoubiquitination is epigenetically important for recruiting replication factor Mcm10 and cohesion establishment factors Ctf4, Ctf18 and Eco1 to early replication origins to establish sister chromatid cohesion.
The synaptic cell adhesion molecule, leucine-rich repeat transmembrane neuronal 1 (LRRTM1), plays an important role in the establishment of retinal convergence onto relay cells in mouse visual thalamus.
Establishing a community of 'rigor champions' and building a comprehensive educational platform to teach the principles of rigorous science will help to ensure that the outputs of scientific research remain reliable and robust.
The organization of layered/laminated axon projections in specific regions of the fruitfly central brain is regulated by short-range repulsive guidance and is critical for local inhibitory circuit formation and function.
Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.