543 results found
    1. Neuroscience

    Lifting the veil on the dynamics of neuronal activities evoked by transcranial magnetic stimulation

    Bingshuo Li, Juha P Virtanen ... Alia Benali
    A cellular-level in vivo investigative method that provides unprecedented insights into the dynamics of neuronal activities evoked by transcranial magnetic stimulation.
    1. Plant Biology

    KATANIN-dependent mechanical properties of the stigmatic cell wall mediate the pollen tube path in Arabidopsis

    Lucie Riglet, Frédérique Rozier ... Thierry Gaude
    KATANIN1 in stigma papilla cells prevents disordered pollen tube growth and straightens pollen tube direction, allowing the pollen tube to find its correct path to the underlying female tissues.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

    Zhe Zhang, Tianlong Zhang ... Jianping Ding
    The GEF activity of Rabex-5 is weakly autoinhibited by its CC domain and activated by Rabaptin-5 and the two proteins work concertedly to activate Rab5.
    1. Structural Biology and Molecular Biophysics

    Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex

    Thomas E Sladewski, Neil Billington ... Kathleen M Trybus
    mRNA cargo orchestrates the activation of an in vitro reconstituted dynein-dynactin-Bicaudal D-Egalitarian complex for robust processive motion on microtubules.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of the SAS-6 cartwheel hub from Leishmania major

    Mark van Breugel, Rainer Wilcken ... Christopher M Johnson
    The X-ray structure of the SAS-6 cartwheel hub from Leishmania major demonstrates that SAS-6 can be sufficient to determine centriolar cartwheel symmetry.
    1. Neuroscience

    The Digital Brain Bank, an open access platform for post-mortem imaging datasets

    Benjamin C Tendler, Taylor Hanayik ... Karla L Miller
    The Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank) provides curated post-mortem imaging datasets for neuroanatomy, neuropathology, and comparative neuroanatomy investigations, with the first release containing 21 distinctive whole-brain diffusion MRI datasets, alongside microscopy and complementary MRI modalities.
    1. Neuroscience

    Comment on "Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans"

    Lukas Landler, Simon Nimpf ... David A Keays
    Employing blinded controlled methodology we find no evidence for a magnetic sense in the nematode worm Caenorhabditis elegans.
    1. Neuroscience

    Response to comment on "Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans"

    Andres Vidal-Gadea, Chance Bainbridge ... Jonathan Pierce-Shimomura
    A reanalysis of data from a challenge by Landler et al. (2018) and our Vidal-Gadea et al. (2015) study reinforce our original finding that C. elegans is a suitable model system to study magnetoreception.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The inner mechanics of rhodopsin guanylyl cyclase during cGMP-formation revealed by real-time FTIR spectroscopy

    Paul Fischer, Shatanik Mukherjee ... Peter Hegemann
    UV-Vis- and IR-spectroscopy provides insights into the light-induced enzyme activity of a rhodopsin guanylyl cyclase by tracking the substrate turnover with atomic resolution in real-time and correlating it with the structural changes of the protein.
    1. Structural Biology and Molecular Biophysics

    Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of ‘quasi-ordered’ states

    Amanda F Clouser, Hannah ER Baughman ... Rachel E Klevit
    Multiple iso-energetic-specific interactions involving the intrinsically-disordered region of sHSP HSPB1 define a quasi-ordered state, providing insights into inherited disease-associated mutations within the region that are thought to be disordered.

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