1,559 results found
    1. Cancer Biology

    Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

    Sumiko Takao et al.
    Definition of leukemia gene expression mechanisms reveals general principles of cancer gene control and offers a pharmacologic strategy for its therapeutic reprogramming.
    1. Developmental Biology

    Cytoplasmic sharing through apical membrane remodeling

    Nora G Peterson et al.
    Apical membrane remodeling in a resorptive Drosophila epithelium generates a shared multinuclear cytoplasm.
    1. Developmental Biology

    Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

    Néstor Saiz et al.
    A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
    1. Cell Biology
    2. Neuroscience

    Pregnancy-associated plasma protein-aa regulates endoplasmic reticulum–mitochondria associations

    Mroj Alassaf, Mary C Halloran
    An extracellular modulator of IGF1 signaling, Pappaa, regulates endoplasmic reticulum–mitochondria connections, which are critical for metabolic homeostasis and hair cell survival.
    1. Structural Biology and Molecular Biophysics

    Molecular structures of the eukaryotic retinal importer ABCA4

    Fangyu Liu et al.
    The structures of ABCA4 in two conformations provide a framework to understand its transport mechanism.
    1. Neuroscience

    Integrative frontal-parietal dynamics supporting cognitive control

    Derek Evan Nee
    Analysis of human fMRI data reveal that intermediary areas within the fronto-parietal control network (FPCN) are critical for integrating control processing, cognitive ability, and amenability to neuromodulation.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate

    Mark S Ladinsky et al.
    Visualization of HIV-1 fusion by trapping the prehairpin intermediate.
    1. Structural Biology and Molecular Biophysics

    Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

    Naotaka Tsutsumi et al.
    Cryo-EM structure of monomeric human Frizzled5 was determined with a universal fiducial antibody at 3.7 Å overall resolution, which supports a simple Fzd/LRP6 heterodimerization mechanism of canonical Wnt/β-catenin signaling.
    1. Neuroscience

    Dopamine neuron ensembles signal the content of sensory prediction errors

    Thomas A Stalnaker et al.
    Dopamine neurons function as an ensemble to signal a multidimensional feature prediction error.
    1. Structural Biology and Molecular Biophysics

    Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870

    Ye Zhou et al.
    The structure of receptor-ligand complex reveals the ligand binding selectivity among different dopamine receptor subtypes and also shows how this ligand class inhibits receptor activity.

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