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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A large effective population size for established within-host influenza virus infection

    Casper K Lumby et al.
    Once an influenza infection is established, selection acts efficiently in favouring fitter viral genotypes, its effects being limited only by the short length of a typical infection.
    1. Chromosomes and Gene Expression

    Intergenerational epigenetic inheritance of cancer susceptibility in mammals

    Bluma J Lesch et al.
    Genetic knockout of the histone demethylase Kdm6a in the mouse germ line leads to elevated cancer incidence in genetically wild type offspring.
    1. Cancer Biology

    A generalized theory of age-dependent carcinogenesis

    Andrii Rozhok, James DeGregori
    The multi-stage model of carcinogenesis requires the incorporation of aging-dependent somatic selection and life history-dependent evolution of species-specific tumor suppressor mechanisms in order to generalize carcinogenesis across tissues and species.
    1. Epidemiology and Global Health

    Estimating effectiveness of case-area targeted response interventions against cholera in Haiti

    Edwige Michel et al.
    Case-area targeted interventions conducted by rapid response teams appeared significantly effective to mitigate and shorten local cholera outbreaks in the Centre department of Haiti in 2015-2017.
    1. Neuroscience

    Induced sensorimotor cortex plasticity remediates chronic treatment-resistant visual neglect

    Jacinta O'Shea et al.
    Tonic disinhibition of left motor cortex during prism adaptation enhanced consolidation of sensorimotor and cognitive prism after effects, causing lasting clinical gains in three patient cases with chronic treatment-resistant visual neglect.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations

    Daniel M Parker et al.
    Given sufficient population adherence, mass drug administration for falciparum malaria can provide group level benefits, also known as ‘herd effects’.
    1. Epidemiology and Global Health

    Relationship between changing malaria burden and low birth weight in sub-Saharan Africa: A difference-in-differences study via a pair-of-pairs approach

    Siyu Heng et al.
    A novel pair-of-pairs matching approach finds that community-level reductions in malaria burden can potentially substantially reduce the low birth weight rate in sub-Saharan Africa, particularly among firstborns.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The origins and relatedness structure of mixed infections vary with local prevalence of P. falciparum malaria

    Sha Joe Zhu et al.
    Variation in the rate of mixed infections by malaria parasites and the relatedness structure among infecting strains reveals diversity in local epidemiological processes.
    1. Neuroscience

    Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity

    Tom P Franken et al.
    The location of impact sounds, common stimuli whose detection is crucial for survival, is encoded by a precise interaction between excitation and inhibition rather than coincidence detection of excitatory events.
  1. Meta-Research: Evaluating the impact of open access policies on research institutions

    Chun-Kai (Karl) Huang et al.
    A longitudinal study of open access levels at 1,207 research institutions worldwide reveals high performing institutions in Latin America, Africa and Asia.