3,859 results found
    1. Microbiology and Infectious Disease

    Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus

    Juan-Carlos García-Betancur et al.
    During Staphylococcus aureus infections, bacterial cells bifurcate into distinct, specialized cell types that localize physically in different colonization tissues to simultaneously generate different infection types.
    1. Epidemiology and Global Health

    Predicting mosquito infection from Plasmodium falciparum gametocyte density and estimating the reservoir of infection

    Thomas S Churcher et al.
    Identifying and treating those groups of individuals that are most likely to transmit the malaria parasite to mosquitoes could help to control the spread of the disease.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

    Laurelle Jackson et al.
    Under conditions where the force of HIV infection per cell is high, partial attenuation of infection with inhibitors can increase the number of live infected cells and may paradoxically be beneficial for viral spread.
    1. Immunology and Inflammation

    High-dimensional analysis of intestinal immune cells during helminth infection

    Laura Ferrer-Font et al.
    A systematic optimization of intestinal digestion protocols allows for the isolation and high-dimensional flow cytometric analysis of intestinal immune cells during murine helminth infection.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

    Alexandre Giraud-Gatineau et al.
    The anti-tuberculosis drug bedaquiline reprograms human macrophages into potent bactericidal phagocytes, which are able to control bacterial infection.
    1. Immunology and Inflammation

    Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

    Eugene Park et al.
    Toxoplasma gondii infection leads to conversion of natural killer cells into cells resembling innate lymphoid cells, group 1, that circulate widely, disrupting current notions suggesting that these cells have distinct lineages.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A large effective population size for established within-host influenza virus infection

    Casper K Lumby et al.
    Once an influenza infection is established, selection acts efficiently in favouring fitter viral genotypes, its effects being limited only by the short length of a typical infection.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Sex-based differences in clearance of chronic Plasmodium falciparum infection

    Jessica Briggs et al.
    Lower malaria prevalence in females does not appear to be due to lower rates of infection but rather due to faster clearance of asymptomatic infections.
    1. Microbiology and Infectious Disease

    Single-cell transcriptional dynamics of flavivirus infection

    Fabio Zanini et al.
    A novel virus-inclusive single cell RNA-Seq approach enables identification of novel pro- and antiviral host factors in human cells in response to dengue and Zika virus infection.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A molecular tweezer antagonizes seminal amyloids and HIV infection

    Edina Lump et al.
    CLR01 is a small molecule that could be an effective topical microbicide to eliminate HIV (and other enveloped viruses), and to antagonize host-encoded amyloid fibrils that promote HIV infection.

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