CNGA3 is a cold-potentiated ion channel that confers cold sensitivity to mouse hypothalamic neurons, whereas CNGA3 from hibernating ground squirrels is cold-insensitive.
Determining that microbiota-deficient mice have increased visceral pain, which can be reversed by restoring microbiota, may lead to novel microbial-based strategies for disorders associated with visceral pain.
Acquisition of antibiotic resistance plasmids induces collateral sensitivity to clinically relevant antibiotics in Escherichia coli, paving the way for targeted 'anti-plasmid' therapies able to preferentially eliminate plasmid-carrying bacteria.
Pre-verbal infants demonstrate an implicit sensitivity to interoceptive sensations, which fluctuates spontaneously during emotional processing and guides audiovisual preferences in the environment.
Highly temperature-sensitive behavior of voltage-gated potassium channels provides a mechanistic model for how heat-activated TRP channels serve as temperature and pain sensors.
Single-cell FRET measurements reveal large temporal activity fluctuations within this signaling pathway in Escherichia coli, caused by stochasticity of receptor methylation combined with allosteric interactions and slow rearrangements within receptor clusters.
Bigger bumblebee eyes have better vision, yet their field of view, sensitivity, and resolution do not all simply scale up with eye size, being improved locally instead.
The anticonvulsant drug lamotrigine inhibits bacterial ribosome biogenesis and reveals an unexplored role for initiation factor 2 (IF2) in ribosome assembly.
Establishing retinal contrast transmission as a novel determinant of mammalian fitness, this research adds functional significance to a prominent exception of nuclear organization, previously described in nocturnal rod photoreceptor cells.
