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    1. Cancer Biology
    2. Computational and Systems Biology

    Defining the biological basis of radiomic phenotypes in lung cancer

    Patrick Grossmann et al.
    Radiomics allows automated quantification of the radiographic phenotype of a tumor across diverse patient cohorts and is connected to the underlying molecular pathway activities, which together determine the clinical outcome.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Protein gradients on the nucleoid position the carbon-fixing organelles of cyanobacteria

    Joshua S MacCready et al.
    Carboxysomes, the carbon-fixation machinery of cyanobacteria, are equidistantly-positioned by dynamic gradients of the protein McdA on the nucleoid that emerge through interaction with a previously unidentified carboxysome factor, McdB.
    1. Ecology

    Climate-driven deoxygenation elevates fishing vulnerability for the ocean's widest ranging shark

    Marisa Vedor et al.
    Habitats of satellite-tracked blue sharks were shifted surfaceward by an oxygen minimum zone (OMZ) at depth thereby increasing their susceptibility to capture by longline fishing focused above the OMZ.
    1. Developmental Biology
    2. Genetics and Genomics

    Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

    Ryan J Geusz et al.
    Analysis of epigenome maps from human pancreatic progenitors and functional validation in zebrafish identify LAMA1 and CRB2 as type 2 diabetes risk-associated genes with roles in pancreatic development.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

    Ricardo Guerrero-Ferreira et al.
    Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.
    1. Immunology and Inflammation
    2. Medicine

    Bacterial–fungal interactions in the neonatal gut influence asthma outcomes later in life

    Rozlyn CT Boutin et al.
    Overgrowth of the yeast Pichia kudriavzevii within the neonatal gut microbiota increases allergic airway disease severity later in life and may be inhibited by short-chain fatty acids.
    1. Neuroscience

    A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila

    Andrew M Seeds et al.
    Gaining genetic control over neural modules that drive the grooming of each Drosophila body part reveals how mechanisms for selecting among competing behavioral choices are used to generate sequences of actions.
    1. Medicine

    TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats

    Marta Gawrys-Kopczynska et al.
    Trimethylamine-oxide (TMAO), a molecule present in seafood, reduces mortality and exerts beneficial effects on the circulatory system in heart failure rats.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function

    Zhenwei Lu et al.
    Diverse biophysical properties of β1 and β3 integrin transmembrane and cytoplasmic domains result in distinct mechanisms of integrin activation and function.
    1. Ecology

    Mummified baboons reveal the far reach of early Egyptian mariners

    Nathaniel J Dominy et al.
    The fabled land of Punt is mapped for the first time using quantitative methods from the disciplines of primatology, geochemistry, and geography.