Cellular and tissue level analysis reveals how different cell behaviors involving dynamics of the basal domain cooperate in space and time to shape an epithelial organ.
Yelena Y Bernadskaya, Haicen Yue ... Alex Mogilner
The migrating pair of cardiac progenitors in the chordate Ciona robusta is the simplest possible supracellular cell collective whose organization helps them overcome resistance from surrounding embryonic tissues during cell migration.
A new computational framework provides a flexible and general approach for single and collective biological motion characterisation and phenotyping ideally suited for high-throughput timelapse screens.
Research on heart tube assembly using zebrafish reveals a pivotal role for intrinsic Pdgfra–PI3K signaling in steering the movement of the myocardium and polarizing myocardial cell protrusions.
Ehsan Sadeghipour, Miguel A Garcia ... Beth L Pruitt
Cell movement toward and away from the midline of an epithelium over tens of hours are caused by spontaneous or externally-applied shear forces to eliminate force imbalances within the tissue.
Eduardo Pulgar, Cornelia Schwayer ... Miguel L Concha
Incomplete delamination serves as a cellular platform for coordinated tissue movements during development, guiding newly formed progenitor cell groups to the differentiation site.
A new example of niche formation, revealing the mode of niche cell migration, implicates extrinsic sources of positional information, and uncovers the pathway required for stereotypical positioning of the niche.
Theory explains how transport of gene expression vortices by cell advection may cause intermingled defective and normal segments along the body axis during resynchronization experiments in the zebrafish segmentation clock.
The evolving spatial distribution of nuclei between apical and basal surfaces of the developing retinal neuroepithelium is quantitatively described by a nonlinear diffusion equation accounting for crowding within the tissue.
