522 results found
    1. Plant Biology

    A virus responds instantly to the presence of the vector on the host and forms transmission morphs

    Alexandre Martinière, Aurélie Bak ... Martin Drucker
    Cauliflower mosaic virus reacts immediately when aphids feed on the host plant, and this boosts its chances of being taken up and transmitted by the insects to a new plant.
    1. Cell Biology

    ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast

    Andrew Murley, Laura L Lackner ... Jodi Nunnari
    Sites at which mitochondria contact the endoplasmic reticulum co-localize the replication of mitochondria and their DNA to help ensure that DNA is distributed appropriately between the newly formed organelles in cells.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    The autoregulation of a eukaryotic DNA transposon

    Corentin Claeys Bouuaert, Karen Lipkow ... Ronald Chalmers
    A DNA transposon, or ‘jumping gene’, controls its amplification within a genome through a competition between the enzyme multimers that are responsible for its mobility.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

    David Bolduc, Meghdad Rahdar ... Philip Cole
    C-terminal phosphorylation of the lipid phosphatase PTEN drives a reduction in membrane affinity and leads to a more compact conformation that involves a C2 domain-tail interaction.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Direct live imaging of cell–cell protein transfer by transient outer membrane fusion in Myxococcus xanthus

    Adrien Ducret, Betty Fleuchot ... Tâm Mignot
    Physical contact between two Myxococcus xanthus cells is sufficient to fuse their outer membrane transiently and exchange outer membrane proteins and lipids at high efficiency.
    1. Developmental Biology

    An essential role for maternal control of Nodal signaling

    Pooja Kumari, Patrick C Gilligan ... Karuna Sampath
    Regulation of conserved Nodal factors by a maternal protein ensures that Nodal signaling is repressed until the appropriate time in embryonic development.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structure of the COPII transport-vesicle coat assembled on membranes

    Giulia Zanetti, Simone Prinz ... John AG Briggs
    A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating heterogeneously-shaped carriers.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Nanoscale protein architecture of the kidney glomerular basement membrane

    Hani Suleiman, Lei Zhang ... Adish Dani
    High-resolution optical microscopy is used to reveal the organization of extracellular matrix proteins within the basement membrane of the blood filtration barrier in the kidney at the nanometer scale.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

    Sigrid Nachtergaele, Daniel M Whalen ... Rajat Rohatgi
    A cysteine-rich domain within the Smoothened receptor may represent a novel therapeutic target for cancers caused by abnormal functioning of the Hedgehog signaling pathway.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation

    Yashar Sadian, Christos Gatsogiannis ... Stefan Raunser
    Imaging with electron microscopy and cryo-electron tomography reveals that competition between Cdc42 and Gic1 for the same subunit within septins controls the formation and breakdown of septin filaments.

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