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    1. Computational and Systems Biology
    2. Physics of Living Systems

    The French flag problem revisited: Creating robust and tunable axial patterns without global signaling

    Stephan Kremser, Gabriel Vercelli, Ulrich Gerland
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

    Arnaud PJ Giese, Wei-Hsiang Weng ... Zubair M Ahmed
    Complexes formed by calcium- and integrin-binding proteins 2 and 3 and transmembrane channel-like proteins 1 and 2 are essential for vertebrate hearing and balance and for fish lateral line function.
    1. Microbiology and Infectious Disease

    Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration

    Malgorzata Broncel, Caia Dominicus ... Moritz Treeck
    Myristoylation of a secreted protein, identified in a global myristoylation analysis of the eukaryotic parasite Toxoplasma gondii, is important for host cell invasion.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

    Nicolas Altemose, Nudrat Noor ... Simon R Myers
    In humans, specific sequence features can predict whether meiotic recombination occurs at sites bound by the protein PRDM9, whose DNA-binding zinc-finger domain can unexpectedly bind to gene promoters and to other copies of PRDM9.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Symbiont-mediated cytoplasmic incompatibility: What have we learned in 50 years?

    J Dylan Shropshire, Brittany Leigh, Seth R Bordenstein
    This review serves as a gateway to experimental, conceptual, and quantitative themes of cytoplasmic incompatibility (CI) and outlines significant gaps in the understanding of CI's mechanism that are ripe for investigation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    EDF1 coordinates cellular responses to ribosome collisions

    Niladri K Sinha, Alban Ordureau ... Rachel Green
    Endothelial Differentiation Factor 1 (EDF1) plays a critical role in driving mRNA-specific quality control and global transcriptional responses in response to ribosome collisions.
    1. Physics of Living Systems

    Mitigating memory effects during undulatory locomotion on hysteretic materials

    Perrin E Schiebel, Henry C Astley ... Daniel I Goldman
    Undulatory animals moving on the surface must manage material memory by either having a slender anatomy that facilitates avoiding previously remodeled substrate, or using waveshapes that effectively utilize the memory.
    1. Cell Biology

    Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration

    Hyunggu Hahn, Carole Daly ... Alex Rojas Bie Thomsen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cancer Biology
    2. Cell Biology

    Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment

    Alexandra Urbancokova, Terezie Hornofova ... Pavla Vasicova
    Chemotherapeutics altering DNA topology evoke RNA polymerase I inhibition, rDNA damage and consequent formation of PNAs that segregate persistent rDNA lesions from the active nucleolus, with implications for rDNA maintenance and design of new cancer treatment strategies targeting rDNA repair.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response

    Edmée Eyraud, Elise Maurat ... Isabelle Dupin
    Intercellular interactions between fibrocytes and CD8+ T lymphocytes promote inflammation through a pathophysiological positive feedback loop in bronchi of patients with chronic obstructive pulmonary disease (COPD).