686 results found
    1. Cancer Biology
    2. Cell Biology

    Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice

    Kai Fu et al.
    Building on previous work (Fu et al., 2016), we demonstrate the critical role of Sam68 in orchestrating genotoxic stress-initiated NF-κB signaling in the colon and the pathophysiological relevance of Sam68-dependent NF-κB activation in colonic cell survival/recovery from extrinsic DNA damage.
    1. Cancer Biology
    2. Cell Biology

    The ESRP1-GPR137 axis contributes to intestinal pathogenesis

    Lukas Franz Mager et al.
    ESRP1 is central to intestinal barrier integrity in mice and humans and alterations in ESRP1 function or expression contribute to intestinal pathology, partly through modified expression of ESRP1-specific GPR137 isoforms.
    1. Cancer Biology
    2. Cell Biology

    AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin

    Nicolas Aznar et al.
    An effector of AMPK is essential for the kinase and its pharmacological activators, including Metformin, to strengthen cell-cell junctions and preserve epithelial cell polarity and barrier functions in the face of energetic stress, as well as to suppress oncogenesis.
    1. Microbiology and Infectious Disease

    Bacterial Immunity: An adaptable defense

    Michael A Schelling, Dipali G Sashital
    The response of bacteria to the threat posed by phages depends on their local environment.
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    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Cell Biology
    2. Evolutionary Biology

    Multicellularity: How contraction has shaped evolution

    Mukund Thattai
    Two new unicellular organisms reveal that coordinated contractions of groups of cells using actomyosin predated animal multicellularity during evolution.
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
    1. Stem Cells and Regenerative Medicine

    Philosophy of Biology: Towards a classification of stem cells

    Lucie Laplane, Eric Solary
    The occurrence, progression and treatment of cancer may be linked to changes in the nature of stemness.
    1. Computational and Systems Biology

    Research: Bias in the reporting of sex and age in biomedical research on mouse models

    Oscar Flórez-Vargas et al.
    A text-mining study suggests that about half of the papers reporting the results of experiments on mice do not report the sex and age of the mice.
    1. Stem Cells and Regenerative Medicine
    2. Human Biology and Medicine

    Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

    Marko Z Nikolić et al.
    Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.

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