4,914 results found
    1. Microbiology and Infectious Disease

    RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies

    Fiona Tulloch et al.
    Attenuating candidate live virus vaccines by incorporating unfavoured codon pairs to reduce translation efficiency is actually mediated though changes in frequencies of CpG and UpA dinucleotides, which make viruses more visible to the innate immune system.
    1. Chromosomes and Gene Expression

    Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides

    Jamie R Wangen, Rachel Green
    Ribosome profiling reveals genome-wide stimulation of stop codon readthrough by aminoglycosides that is influenced sequence context.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer

    Karthikeyani Chellappa et al.
    Proper gut health depends on the balance between two naturally occurring variants of a transcription factor in the colon.
    1. Cell Biology
    2. Cancer Biology

    Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

    Seung-Hyun Ro et al.
    Sestrin2 loss could be a universal mechanism of human colon carcinogenesis that allows for barrier dysfunction, mTORC1 hyperactivation, unrestricted tumor growth and chemoresistance.
    1. Neuroscience

    Monkey EEG links neuronal color and motion information across species and scales

    Florian Sandhaeger et al.
    Using Monkey EEG as a bridge technology, color and motion representations in human MEG are linked to microcircuit activity in ventral stream areas.
    1. Cell Biology
    2. Ecology

    Quantitative 3D-imaging for cell biology and ecology of environmental microbial eukaryotes

    Sebastien Colin et al.
    Three-dimensional fluorescence imaging of microbial eukaryotes in environmental samples allows accurate automated taxonomic profiling and quantitative data about ultrastructures and interactions of organisms.
    1. Evolutionary Biology

    A β-carotene-binding protein carrying a red pigment regulates body-color transition between green and black in locusts

    Meiling Yang et al.
    Body color change of locusts reveals a new 'palette effect' mechanism by which the red βCBP–β-carotene pigment complex acts as a switch to coordinate between black and green coloration.
    1. Cancer Biology

    Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

    Andrea Sacchetti et al.
    Colon cancer cells disseminate and colonize distant organ sites along the invasion-metastasis cascade by transiently activating intermediate epithelial to mesenchymal transition states through distinct transcriptional trajectories.
    1. Cell Biology
    2. Evolutionary Biology

    Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster

    Joshua G Dunn et al.
    Ribosomes translate through stop codons far more often than previously thought, yielding C-terminally extended proteins in a variety of eukaryotes.
    1. Chromosomes and Gene Expression

    Kinetic competition during the transcription cycle results in stochastic RNA processing

    Antoine Coulon et al.
    Real-time single-molecule visualization of transcription and splicing in living cells reveals that RNA synthesis and processing can occur through multiple pathways on the same gene.

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