3,352 results found
    1. Neuroscience

    Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo

    Taisuke Miyazaki et al.
    Excitatory and inhibitory postsynaptic receptors are maintained at corresponded postsynaptic sites with the different dependency of presynaptic neurons in the mature mammalian brain.
    1. Neuroscience

    Evidence for a deep, distributed and dynamic code for animacy in human ventral anterior temporal cortex

    Timothy T Rogers et al.
    Signals recorded directly from human anterior temporal cortex reveal that the brain represents animacy information using a distributed code that changes radically as a stimulus is processed, as predicted by an artificial neural network model.
    1. Cell Biology
    2. Developmental Biology

    Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

    Maureen C Lamb et al.
    Collectively migrating cells control their stiffness by Fascin-dependent control of Myosin activity, and this migratory cell stiffness regulates Myosin activity and stiffness within the cellular substrate to ultimately promote migration.
    1. Biochemistry and Chemical Biology

    Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

    Maria Carmela Filomena et al.
    Ablation of the sarcomeric protein myopalladin (MYPN), associated with human cardiomyopathies, results in dilated cardiomyopathy, which is severely aggravated by biomechanical stress, suggesting that skeletal myopathy patients carrying MYPN loss-of-function mutations may develop cardiomyopathy under conditions of cardiac stress.
    1. Neuroscience

    Auditory sensory deprivation induced by noise exposure exacerbates cognitive decline in a mouse model of Alzheimer’s disease

    Fabiola Paciello et al.
    Central damage and sensory deprivation caused by noise-induced hearing loss in the pre-symptomatic Alzheimer's disease (AD) phase can compromise auditory cortex-hippocampal circuitry, targeting common pathogenetic pathways, thereby accelerating onset and progression of AD phenotype.
    1. Ecology

    Echolocating toothed whales use ultra-fast echo-kinetic responses to track evasive prey

    Heather Vance et al.
    Echolocating toothed whales can detect and react to sudden prey movements during close approaches with speeds similar to ultra-fast tracking responses in human vision.
    1. Neuroscience

    Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition

    Domenico Pimpinella et al.
    Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.
    1. Neuroscience

    Visual pursuit behavior in mice maintains the pursued prey on the retinal region with least optic flow

    Carl D Holmgren et al.
    Digital reconstruction of environment combined with eye and head-tracking enabled the process of prey-detection and capture to be seen from the freely moving mouse’s point-of-view and shows the exact visual-field and retinal location mice use when chasing prey and the advantage.
    1. Microbiology and Infectious Disease

    Pathogen clonal expansion underlies multiorgan dissemination and organ-specific outcomes during murine systemic infection

    Karthik Hullahalli, Matthew K Waldor
    During Escherichia coli systemic infection, the replication of a minuscule fraction of the inoculum drives organ-specific clearance failures, systemic dissemination, and stochastic infection outcomes.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Multicolor fluorescence fluctuation spectroscopy in living cells via spectral detection

    Valentin Dunsing et al.
    Fluorescence fluctuation spectroscopy is implemented for detection of up to four molecular species, allowing users to quantify molecular interactions and stoichiometry of multicomponent complexes in live cells, in a wide range of biological processes, from membrane signaling to viral assembly.

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