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    1. Cancer Biology

    Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

    Ritu Chaudhary et al.
    Functional and mechanistic analysis of p53-regulated lncRNA PINCR and its interacting RNA-binding protein Matrin 3 uncovers context-dependent regulation of specific p53 target genes during DNA damage.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Microbiome: Does disease start in the mouth, the gut or both?

    Andrei Prodan et al.
    Oral bacteria colonize the gut more frequently than previously thought.
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    1. Cancer Biology

    Reproducibility in Cancer Biology: The who, where and how of fusobacteria and colon cancer

    Cynthia L Sears
    The association between the bacterium Fusobacterium nucleatum and human colon cancer is more complicated than it first appeared.
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    1. Cancer Biology
    2. Immunology and Inflammation

    Topography of cancer-associated immune cells in human solid tumors

    Jakob Nikolas Kather et al.
    Spatial patterns of lymphoid and myeloid cells in human solid tumors differ between cancer types, yielding a new classification of anti-tumor host response.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications

    Sebastià Franch-Expósito et al.
    CNApp is a novel and unique web-based software that enables the performance of comprehensive and integrative analysis of genomic copy number alterations to uncover new associations with patient-oriented relevance.
    1. Cancer Biology

    Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

    John Repass, Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
    1. Stem Cells and Regenerative Medicine

    Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis

    Yuhua Tian et al.
    miR-31 drives proliferation of intestinal stem cells, and protects intestinal stem cells against apoptosis both during homeostasis and regeneration in response to ionizing radiation injury, and promotes intestinal tumorigenesis through regulation of multiple signaling pathways.
    1. Chromosomes and Gene Expression

    A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

    Ryan W Serra et al.
    A pathway directed by the KRAS oncoprotein leads to aberrant hypermethylation and transcriptional silencing of many genes including tumor suppressors, thereby promoting tumor development.