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    1. Developmental Biology
    2. Evolutionary Biology

    Cortex cis-regulatory switches establish scale colour identity and pattern diversity in Heliconius

    Luca Livraghi, Joseph J Hanly ... Chris D Jiggins
    The evolution of a butterfly mimetic phenotype is driven by modular cis-regulstory switches controlling a ‘hotspot’ gene.
    1. Cell Biology
    2. Developmental Biology

    Tight Junction Protein 1a regulates pigment cell organisation during zebrafish colour patterning

    Andrey Fadeev, Jana Krauss ... Christiane Nüsslein-Volhard
    The changes in shape of iridophores that underlie adult colour pattern formation in zebrafish depend on the levels of Tight Junction Protein 1a in these cells.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity

    Conor J Howard, Victor Hanson-Smith ... Liam J Holt
    Reconstructing ancestral enzymes has revealed that a switch in kinase substrate preference evolved via an expanded specificity intermediate that is tolerated in vivo, thus providing a path for kinase diversification.
    1. Immunology and Inflammation

    Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor

    Chenchen Mao, Yanyu Chen ... Xiangyang Xue
    Resting natural killer cells promote the progress of colon cancer liver metastasis (CCLM), which may be exploited for novel strategies to improve therapeutic outcomes for patients with CCLM.
    1. Ecology
    2. Evolutionary Biology

    Contrasting parental roles shape sex differences in poison frog space use but not navigational performance

    Andrius Pašukonis, Shirley Jennifer Serrano-Rojas ... Lauren A O'Connell
    Extensive field studies in poison frogs reveal that sex and species differences in parental behavior drive differences in space use patterns but not navigational performance and highlight the interplay between androgen levels and poison frog spatial behavior.
    1. Neuroscience

    anTraX, a software package for high-throughput video tracking of color-tagged insects

    Asaf Gal, Jonathan Saragosti, Daniel JC Kronauer
    anTraX is an algorithm and software package that facilitates automated analyses of insect social behavior in species and experimental settings that are not accessible with currently existing technology.
    1. Cancer Biology

    miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis

    Lihua Wang, Ergang Wang ... Xiling Shen
    miR-34a prevents inflammation-induced colonic regeneration from oncogenesis by simultaneously targeting processes in both immune and epithelial cells, including T helper 17 cell differentiation, recruitment, and IL-17 induced epithelial proliferation.
    1. Immunology and Inflammation

    α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster

    Oliver Gordon, Conor M Henry ... Caetano Reis e Sousa
    The Drosophila response to injection of alpha-actinin reinforces the notion that exposure of cytoskeletal components acts as a sign of cell damage conserved throughout metazoan evolution.
    1. Neuroscience

    Generalization of learned responses in the mormyrid electrosensory lobe

    Conor Dempsey, LF Abbott, Nathaniel B Sawtell
    In vivo recordings and computational modeling of the electrosensory lobe of mormyrid fish provide a circuit-level description of how learning generalizes to new situations.
    1. Cancer Biology

    Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

    Jae Hun Shin, Jooyoung Park ... Alfred LM Bothwell
    DKK2 is crucial for the development of lysozyme-expressing cancer cells with Paneth cell characteristics necessary for liver metastasized colon cancer growth.