9,248 results found
    1. Computational and Systems Biology
    2. Neuroscience

    The interpretation of computational model parameters depends on the context

    Maria Katharina Eckstein, Sarah L Master ... Anne GE Collins
    Context factors such as experimental task and model parameterization can significantly impact modeling results, such that across tasks, the same participants show different fitted parameter values, and parameters capture different cognitive processes across tasks.
    1. Developmental Biology

    Pitx2c orchestrates embryonic axis extension via mesendodermal cell migration

    Michelle M Collins, Hans-Martin Maischein ... Didier YR Stainier
    Expression of Pitx2c at the onset of gastrulation drives convergence and extension movements in the zebrafish embryo by promoting downstream pathways affecting chemokine signaling, integrin-ECM interactions, and planar cell polarity components.
    1. Genetics and Genomics

    Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation

    Mahlon A Collins, Gemechu Mekonnen, Frank Wolfgang Albert
    Genetic mapping reveals widespread, complex genetic effects on protein degradation by the ubiquitin-proteasome system, the primary protein degradation pathway in eukaryotic cells.
    1. Cell Biology
    2. Developmental Biology

    Limited column formation in the embryonic growth plate implies divergent growth mechanisms during pre- and postnatal bone development

    Sarah Rubin, Ankit Agrawal ... Elazar Zelzer
    Modulation of division plane rotation in proliferating chondrocytes determines the ratio of clusters and columns, which may support the multifunctional design of the growth plate.
    1. Developmental Biology
    2. Genetics and Genomics

    A high-resolution mRNA expression time course of embryonic development in zebrafish

    Richard J White, John E Collins ... Elisabeth M Busch-Nentwich
    Global gene expression analysis defines the transcriptional events during the development of zebrafish from fertilised egg to fully formed organism.
    1. Evolutionary Biology

    Evolution and diversity of biomineralized columnar architecture in early Cambrian phosphatic-shelled brachiopods

    Zhiliang Zhang, Zhifei Zhang ... Guoxiang Li
    Columnar architectures, developed in early Cambrian phosphatic-shelled brachiopods, are highly biologically controlled and organic-matrix mediated, which sheds new light on the evolution and adaptation of biomineralization during the Cambrian explosion.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis

    Blessy Paul, Hyun Sung Kim ... Brett M Collins
    Chlamydia hijacks membrane trafficking proteins of the human host via the cytoplasmic domain of a secreted transmembrane protein.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni

    George R Wendt, Julie NR Collins ... James J Collins III
    The specification of tegumental progenitor cells in Schistosoma mansoni relies on a pair of flatworm-specific transcription factors that are related to genes regulating epidermal specification in free-living flatworms.
    1. Stem Cells and Regenerative Medicine
    2. Microbiology and Infectious Disease

    Stem cell progeny contribute to the schistosome host-parasite interface

    James J Collins III, George R Wendt ... Phillip A Newmark
    Stem cells are found to continually rejuvenate the epidermis of the human parasite Schistosoma mansoni.
    1. Neuroscience

    Functional interactions among neurons within single columns of macaque V1

    Ethan B Trepka, Shude Zhu ... Tirin Moore
    A proof-of-principle is provided for the use of high-density neurophysiological recordings in assessing local circuit interactions within the macaque brain.

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