372 results found
    1. Neuroscience

    The role of premature evidence accumulation in making difficult perceptual decisions under temporal uncertainty

    Ciara A Devine et al.
    Temporal uncertainty interferes with the timely onset of evidence accumulation in perceptual decision making prompting the brain to rely instead on statistical regularities in the temporal structure of the environment.
    1. Evolutionary Biology

    Retinal oxygen supply shaped the functional evolution of the vertebrate eye

    Christian Damsgaard et al.
    Multiple respiratory and vascular mechanisms have recurrently evolved across the vertebrates to alleviate the oxygen diffusion limitations inherent to the morphology of the retina.
    1. Developmental Biology

    Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation

    Maria R Stupnikov et al.
    Notch ligands from the Delta and Jagged families have distinct roles in epithelial progenitor cell fate of extrapulmonary and intrapulmonary airways and differentially restrict expansion of the neuroendocrine microenvironment.
    1. Neuroscience

    Ten simple rules for the computational modeling of behavioral data

    Robert C Wilson, Anne GE Collins
    Computational modeling of cognitive and neuroscience data is an insightful and powerful tool, but has many potential pitfalls that can be avoided by following simple guidelines.
    1. Cell Biology
    2. Developmental Biology

    Multiplex live single-cell transcriptional analysis demarcates cellular functional heterogeneity

    Ayhan Atmanli et al.
    A novel live-cell mRNA imaging technology identifies individual living cells based on their gene expression and enables the concurrent study of their physiology.
    1. Plant Biology

    Dynamic ubiquitination determines transcriptional activity of the plant immune coactivator NPR1

    Michael J Skelly et al.
    Expression of plant immune genes is controlled by the opposing actions of ubiquitin ligases and deubiquitinases that modify the master coactivator NPR1, thereby regulating its intrinsic transcriptional activity.
    1. Microbiology and Infectious Disease

    Research Culture: Co-reviewing and ghostwriting by early-career researchers in the peer review of manuscripts

    Gary S McDowell et al.
    Early career researchers commonly peer review manuscripts on behalf of invited reviewers, often without receiving feedback or being named to the journal.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

    Murilo Delgobo et al.
    Mycobacterium tuberculosis exploits an IFN/IL6/CEBP axis linked to monocyte expansion in humans.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection

    Pengxing Cao et al.
    A mathematical model of blood-stage infection with Plasmodium falciparum malaria capturing the sexual stage of the parasite life-cycle is validated against human data, providing new insight into human-to-mosquito transmission.
    1. Epidemiology and Global Health
    2. Human Biology and Medicine

    Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

    Ceereena Ubaida-Mohien et al.
    The changes in the skeletal muscle proteome with age indicate the roots of the decline in muscle function with age.

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