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    1. Cell Biology

    Reliable cell cycle commitment in budding yeast is ensured by signal integration

    Xili Liu et al.
    The decision to commit to cell division-the Start transition-in budding yeast is governed by time integration of G1 cyclin-CDK activity by the transcription factor Whi5.
    1. Cancer Biology
    2. Cell Biology

    Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

    Anna Shemorry et al.
    Biochemical and biological studies reveal that caspases feed back onto the Unfolded Protein Response by cleaving the ER-stress sensor IRE1 to produce a cytoprotective N-terminal fragment that inhibits BAX-dependent apoptosis.
  1. Research funders renew commitment to transforming science publishing

    Our announcement that eLife's three founders are extending their funding of the initiative generated coverage in Nature, Times Higher Education and more.
    1. Developmental Biology

    The Hox transcription factor Ubx stabilizes lineage commitment by suppressing cellular plasticity in Drosophila

    Katrin Domsch et al.
    The Hox transcription factor Ultrabithorax (Ubx) represses alternative gene programs during lineage development by lineage-specific Polycomb protein complex retention at Ubx-targeted chromatin sites.
    1. Epidemiology and Global Health

    Coverage and system efficiencies of insecticide-treated nets in Africa from 2000 to 2017

    Samir Bhatt et al.
    Insecticide-treated net requirements for Africa have been underestimated, but mitigating for inefficiencies in net distributions can produce a cost effective path to universal coverage.
    1. Developmental Biology

    Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling

    Xin Huang et al.
    Post-implantation epiblast maturation and patterning of anterior-posterior axis in mouse embryonic development are mediated by pluripotency transcription factor Zfp281 through transcriptional and epigenetic control of Nodal signaling.
    1. Neuroscience

    Neural evidence accumulation persists after choice to inform metacognitive judgments

    Peter R Murphy et al.
    Error detection is contingent on the continuation of evidence accumulation after choice commitment, and the speed and accuracy of this process are modulated by high-level signals from medial frontal cortex.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Polycomb enables primitive endoderm lineage priming in embryonic stem cells

    Robert S Illingworth et al.
    Polycomb enables lineage priming in mouse embryonic stem cells by establishing a barrier to commitment.
    1. Developmental Biology

    Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo

    Eszter Posfai et al.
    Lineage specification and commitment are synchronized in the developing trophectoderm lineage of the mouse embryo, but are asynchronous events in the maturing inner cell mass, revealing a window of plasticity in this lineage.
    1. Developmental Biology
    2. Physics of Living Systems

    Gene-free methodology for cell fate dynamics during development

    Francis Corson, Eric D Siggia
    Mathematical methods based on geometry that directly embody the developmental concepts of competency, commitment, and determination provide succinct descriptions of morphogenesis and allow quantitative predictions from fits to sparse genetic data in Caenorhabditis elegans.