Kenichi Shimada, John A Bachman ... Timothy J Mitchison
shinyDepMap helps users explore the essentiality, selectivity, and function of the genes across hundreds of cancer cell lines and identify cancer drug targets.
Regulatory elements in an mRNA that act in cis to influence translation can also exert their effects in trans, in a process dependent on assembly of the mRNAs into particles.
Dakota E McCoy, Benjamin Goulet-Scott ... John Kartesz
Across 63 large US cities, street tree communities are shaped by climate, clustered by species, and made more similar between cities due to the presence of introduced species.
Understanding novel cell types and their evolutionary history is re-evaluated using single nuclei transcriptomic approaches and their inferred underlying gene regulatory networks.
Fabrice Jean-Pierre, Thomas H Hampton ... George A O'Toole
A cystic fibrosis (CF) lung microbiome-informed in vitro polymicrobial system allows for a mechanistic understanding of community-specific tolerance of Pseudomonas aeruginosa to a front-line CF antimicrobial.
Environmental DNA from highly standardized leaf sample time series suggests no localized species losses, but biotic turnover and homogenization, as main drivers of forest insect decline.
Chiara Vanni, Matthew S Schechter ... Antonio Fernàndez-Guerra
A newly developed computational framework provides an overview of the extent, diversity, and relevance of the genes of unknown function in genomes and metagenomes.