506 results found
    1. Medicine
    2. Neuroscience

    mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

    Philip Stavrides, Chris N Goulbourne ... Dun-Sheng Yang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Progesterone induces meiosis through two obligate co-receptors with PLA2 activity

    Nancy Nader, Lama Assaf ... Khaled Machaca
    Progesterone mediates nongenomic signaling in Xenopus oocyte meiosis by activating a PLA2 activity that requires two membrane receptors ABDH2 and mPRß.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Risk factors affecting polygenic score performance across diverse cohorts

    Daniel Hui, Scott Dudek ... Marylyn D Ritchie
    Numerous related sample characteristics affect polygenic score performance, and incorporation of interaction effects increases both model and polygenic score performance.
    1. Biochemistry and Chemical Biology

    Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

    Gabriella O Estevam, Edmond M Linossi ... James S Fraser
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    A double dissociation between semantic and spatial cognition in visual to default network pathways

    Tirso RJ Gonzalez Alam, Katya Krieger-Redwood ... Elizabeth Jefferies
    Default mode network and visual cortex are connected via two parallel pathways that differentially respond to the processing of visual scenes and semantic information about objects, reflecting domain-specific organisation.
    1. Neuroscience

    Multi-study fMRI outlooks on subcortical BOLD responses in the stop-signal paradigm

    Scott Isherwood, Sarah A Kemp ... Birte Forstmann
    A novel meta-analytical method aggregating five SST datasets does not find evidence for the innervation of the hyperdirect or indirect cortico-basal-ganglia pathways in successful response inhibition.
    1. Neuroscience

    Tripartite organization of brain state dynamics underlying spoken narrative comprehension

    Lanfang Liu, Jiahao Jiang ... Guosheng Ding
    Hidden Markov Modeling to fMRI data reveals how language comprehension arises from the dynamic interplay of large-scale brain networks.
    1. Neuroscience

    Canonical neurodevelopmental trajectories of structural and functional manifolds

    Alicja Monaghan, Richard. AI Bethlehem ... Duncan E Astle
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology
    2. Physics of Living Systems

    A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

    David Trombley McSwiggen, Helen Liu ... Hilary P Beck
    Single-molecule tracking at scale, analyzing millions of cells and thousands of compounds per day, demonstrates that measuring protein motion provides mechanistic insights relevant to drug discovery.
    1. Neuroscience

    Multi-dimensional social relationships shape social attention in monkeys

    Sainan Liu, Jiepin Huang ... Yan Yang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing

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