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    1. Epidemiology and Global Health
    2. Medicine

    Cardiovascular disease and subsequent risk of psychiatric disorders: a nationwide sibling-controlled study

    Qing Shen, Huan Song ... Unnur Valdimarsdóttir
    Patients diagnosed with a cardiovascular disease are at higher risk of psychiatric disorders, independent of familial factors shared between full siblings and comorbid conditions.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection

    Flora Mikaeloff, Marco Gelpi ... Ujjwal Neogi
    Multi-omics-driven patient stratification identify at-risk profile of metabolic complications in people living with HIV on suppressive therapy that need clinical attention.
    1. Epidemiology and Global Health

    The impact of COVID-19 on cancer screening and treatment in older adults: The Multiethnic Cohort Study

    Victoria P Mak, Kami White ... Loic Le Marchand
    During the COVID-19 pandemic, cancer-related screening and healthcare practices varied (by age, race/ethnicity, education, and comorbidities), and considering these differences in high-risk individuals' monitoring is important as undiagnosed cases or poor prognosis may increase due to delayed screening/treatment.
    1. Neuroscience

    Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease

    Osman Shabir, Ben Pendry ... Jason Berwick
    Mice modelling atherosclerosis show neurovascular breakdown in the cortex compared to healthy controls, and inducing atherosclerosis in mice modelling Alzheimer's disease increases the number of amyloid plaques in the hippocampus.
    1. Computational and Systems Biology
    2. Medicine

    Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study

    Riku Klén, Disha Purohit ... David Gómez-Varela
    The generalizability of CODOP in distinct world regions and its flexibility to reckon with the changing availability of hospital resources makes it a clinically useful tool potentially improving the outcome prediction and the management of COVID-19 hospitalized patients.
    1. Microbiology and Infectious Disease

    Comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’

    Ethan S FitzGerald, Amanda M Jamieson
    We are writing to comment on an article by Mast et al., 2021, about the drivers of coagulopathy in the lungs of COVID-19 patients.
    1. Immunology and Inflammation
    2. Medicine

    The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline

    Danielle Janosevic, Jered Myslinski ... Pierre C Dagher
    Single-cell RNA-sequencing identifies the precise cellular and molecular events that occur along the sepsis timeline in the kidney, pointing to potential biomarkers and therapeutic targets.
    1. Neuroscience

    Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy

    Pablo M Casillas-Espinosa, Alison Anderson ... Terence J O'Brien
    Sodium selenate is the first treatment with persistent disease-modifying effects reducing seizures and improving cognitive deficits, in chronically epileptic and drug-resistant TLE animals.
    1. Epidemiology and Global Health
    2. Medicine

    Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort

    ISARIC Clinical Characterisation Group, Matthew D Hall ... Piero L Olliaro
    Patient outcomes, and the time spent by patients during hospital admission, showed considerable variation over the first year of the COVID-19 pandemic.
    1. Immunology and Inflammation

    Seroconversion stages COVID19 into distinct pathophysiological states

    Matthew D Galbraith, Kohl T Kinning ... Joaquín M Espinosa
    Stratification of COVID19 patients using quantitative metrics of seroconversion reveals distinct pathophysiological stages after SARS-CoV-2 infection, including key differences in immune cell types, inflammatory makers, and markers of organ function.