Mice modelling atherosclerosis show neurovascular breakdown in the cortex compared to healthy controls, and inducing atherosclerosis in mice modelling Alzheimer's disease increases the number of amyloid plaques in the hippocampus.
Nathella Pavan Kumar, Kiyoshi F Fukutani ... Hardy Kornfeld
Systemic inflammation is greater in individuals with concurrent TB and diabetes than in euglycemic individuals with TB, and this disparity persists through the full 6-month course of anti-tubercular treatment.
Jeffrey Thompson, Yidi Wang ... Ulrich H von Andrian
A claims-based retrospective cohort study shows that patients who used bisphosphonates between 01/01/2019 and 02/29/2020 had dramatically reduced odds of SARS-CoV-2 testing, COVID-19 diagnosis, and COVID-19-related hospitalizations during the initial surge of the COVID-19 pandemic in the US.
Rashmi Sukumaran, Achuthsankar S Nair, Moinak Banerjee
Genomic differences in stroke and its comorbid conditions can aid in refining the socio-economic interpretation of risk among different ethnicities and can assist in distinguishing their phenotypic variation.
Alexander O Pasternak, Jelmer Vroom ... The Co-morBidity in Relation to Aids (COBRA) Collaboration
In two independent cohorts, NNRTI-based cART regimens are associated with significantly lower cell-associated HIV RNA levels than PI-based regimens, suggesting more potent suppression of residual virus replication by NNRTI-based regimens.
Patients diagnosed with a cardiovascular disease are at higher risk of psychiatric disorders, independent of familial factors shared between full siblings and comorbid conditions.
Daniel W Belsky, Avshalom Caspi ... Terrie E Moffitt
DunedinPACE is a novel DNA methylation biomarker of the pace of biological aging for intervention trials and natural experiment studies investigating how the rate of aging may be changed by behavioral or drug therapy, or by environmental modification.
The lifespan of individuals who suffer from an osteoporotic fracture is reduced by between 1 and 7 years, depending on the location of the fracture and their risk profile, suggesting that their 'Skeletal Age' is higher than their chronological age.
Analysis of proteomic data identified protein biomarkers of aging, mortality and aging-related diseases, supporting their use to monitor aging trajectories and identify individuals at higher risk of disease.
