1,480 results found
    1. Neuroscience

    Hippocampal pattern completion is linked to gamma power increases and alpha power decreases during recollection

    Bernhard P Staresina et al.
    Direct recordings from the human hippocampus reveal the neural mechanisms that orchestrate recollection of past experiences.
    1. Cell Biology
    2. Developmental Biology

    Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation

    Masatoshi Hara et al.
    The kinase that controls maternal mRNA translation is regulated by phosphorylation of its activating subunit to restrict kinase activity to the developmental window between meiosis completion and early embryogenesis.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Single-molecule observation of DNA compaction by meiotic protein SYCP3

    Johanna L Syrjänen et al.
    Building on previous work (Syrjänen, Pellegrini, & Davies, 2014), it is shown that SYCP3 contributes to the architecture of meiotic chromosomes through local bridging interactions that result in large-scale compaction of the chromosome axis.
    1. Cell Biology

    Axial contraction and short-range compaction of chromatin synergistically promote mitotic chromosome condensation

    Tom Kruitwagen et al.
    Condensation and segregation of chromosomes during mitosis is caused by a combination of short-range interactions between nucleosomes and the long-range contraction of chromosome arms mediated by condensin.
    1. Cell Biology
    2. Evolutionary Biology

    Evolution of histone 2A for chromatin compaction in eukaryotes

    Benjamin R Macadangdang et al.
    The N-terminal domain in histone 2A serves as an evolutionary tool to enable greater chromatin compaction when genome size is disproportionately larger than the nuclear volume across eukaryotes.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation

    Shengbo He et al.
    Transposon activation during male gametogenesis is caused by interactions between DNA demethylation and linker histone H1, developmental depletion of which promotes pollen fertility.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Compaction and segregation of sister chromatids via active loop extrusion

    Anton Goloborodko et al.
    Loop extrusion can robustly compact, segregate and disentangle mammalian chromosomes, suggesting it is a universal mechanism of genome folding during cell division.
    1. Neuroscience

    Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults

    Alexandra N Trelle et al.
    The strength of pattern completion during memory retrieval, indexed by hippocampal activity and cortical reinstatement, explains within- and across-individual variability in episodic memory in older adults.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    The interplay between asymmetric and symmetric DNA loop extrusion

    Edward J Banigan, Leonid A Mirny
    Models of chromosome compaction by condensins demonstrate that two-sided loop extrusion and long residence times are required for high compaction, suggesting a tight coupling between these two properties in vivo.
    1. Biochemistry and Chemical Biology

    Gradual compaction of the nascent peptide during cotranslational folding on the ribosome

    Marija Liutkute et al.
    HemK NTD cotranslational folding starts within the ribosome exit tunnel upon N-terminal helix synthesis and proceeds sequentially through a series of intermediates becoming less dynamic as the nascent chain grows.

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