156 results found
    1. Stem Cells and Regenerative Medicine

    Physiological and stem cell compartmentalization within the Drosophila midgut

    Alexis Marianes, Allan C Spradling
    The intestine contains distinct subregions specialized for digestion along its anterior-posterior axis, and the stem cells that constantly renew these subregions are not interchangeable.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

    David Trombley McSwiggen et al.
    Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver

    Bryan J Matthews, David J Waxman
    Certain types of 3D chromatin loops are easy to predict from existing or easily obtainable 2D information, which benefits gene expression studies in tissues/cells/organisms without extensive pre-existing 3D information.
    1. Cell Biology

    PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

    Stefania Monterisi et al.
    The enzyme phosphodiesterase 2A2 localises at the mitochondrial membrane and its inhibition results in a local increase in cAMP concentration, mitochondrial elongation and resistance to apoptosis.
    1. Cell Biology

    A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell

    Lori Clay et al.
    Sphingolipids govern the compartmentalization of yeast cells through the assembly of lateral diffusion barriers in ER membranes.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors

    Ofer Rog et al.
    Formation of a phase-separated interface between homologous chromosomes during meiosis enables regulatory signals to spread in cis over long distances, illuminating the longstanding mystery of crossover interference.
    1. Cell Biology

    Oscillatory phase separation in giant lipid vesicles induced by transmembrane osmotic differentials

    Kamila Oglęcka et al.
    Spontaneous osmoregulation in giant phospholipid vesicles, which is characterized by oscillations in vesicle size and membrane tension, couples to the compositional degrees of freedom at the membrane surface to produce oscillations in domain texture and induce isothermal phase change.
    1. Developmental Biology

    Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis

    Kenzo Ivanovitch et al.
    Tissue-level coordination of cardiac progenitor cells in the early mouse embryo produces a temporal compartmentalization of differentiation and morphogenesis essential for heart tube formation.
    1. Developmental Biology

    Reproduction: What is a placental mammal anyway?

    Patrick Abbot, John A Capra
    Many developmental functions in marsupials and eutherian mammals are accomplished by different tissues, but similar genes.
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking

    Pornchai Kaewsapsak et al.
    Live-cell nanometer-resolution RNA labeling method enables transcriptome-wide mapping of endogenous RNAs in nuclear, cytosol, ER, and mitochondrial subcompartments.

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