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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation

    André Mourão, Sophie Bonnal ... Michael Sattler
    Interactions with Sm proteins can provide a way in which regulatory factors can modulate alternative splice site choices.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Rapid cloning-free mutagenesis of new SARS-CoV-2 variants using a novel reverse genetics platform

    Enja Tatjana Kipfer, David Hauser ... Thomas Klimkait
    CLEVER enables the rapid manipulation and direct rescue of plus-strand RNA viruses with the shortest hands-on time to study viral variants of concern.
    1. Neuroscience

    Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice

    Andres P Varani, Caroline Mailhes-Hamon ... Daniela Popa
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Microbiology and Infectious Disease

    A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria

    John C Whitney, S Brook Peterson ... Joseph D Mougous
    Diverse LXG toxins delivered by the Esx pathway function as mediators of contact-dependent interbacterial antagonism within and between Gram-positive bacterial species.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis

    Haik Mkhikian, Christie-Lynn Mortales ... Michael Demetriou
    Structurally dissimilar N-glycans can be functionally equivalent, and are produced via a self-correcting feature of the Golgi.
    1. Cell Biology

    Caveolae couple mechanical stress to integrin recycling and activation

    Fidel-Nicolás Lolo, Dácil María Pavón ... Miguel A del Pozo
    Caveolae regulate integrin mechanosensing by establishing a force threshold for activation and recycling.
    1. Neuroscience

    Dorsolateral prefrontal activity supports a cognitive space organization of cognitive control

    Guochun Yang, Haiyan Wu ... Jiefeng Jiang
    The dorsolateral prefrontal cortex represents different conflict types within an organized cognitive space of cognitive control, positioning more similar conflict types closer together.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria

    Matthieu Bergé, Sébastien Campagne ... Patrick H Viollier
    Common ancestries, activities and structural determinants of a modular (bi-)polarization control system encoded in free-living and obligate intracellular α-proteobacteria, including the rickettsial pathogens, are described.
    1. Epidemiology and Global Health

    Anopheles salivary antigens as serological biomarkers of vector exposure and malaria transmission: A systematic review with multilevel modelling

    Ellen A Kearney, Paul A Agius ... Freya JI Fowkes
    A systematic review with multilevel modelling quantified the positive association between human antibodies to Anopheles salivary proteins with Anopheles-human biting rate and epidemiological measures of malaria transmission, highlighting their potential as a tool to measure vector exposure and malaria transmission.
    1. Cancer Biology
    2. Cell Biology

    Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation

    Ashna Alladin, Lucas Chaible ... Martin Jechlinger
    The presented primary epithelial acinus-based platform for studying interactions between normal and malignant cells will enable in depth analysis of the tumor initiation process on a molecular level.