552 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds

    Cristina Manatschal et al.
    The structural and mechanistic characterization of competitive inhibition of human DMT1 offers a promising route for the development of compounds for the treatment of iron overload disorders.
    1. Neuroscience

    Motor Control: A choice motif

    Sabine L Renninger, Michael B Orger
    Insight
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    1. Biochemistry and Chemical Biology

    Science Forum: Donated chemical probes for open science

    Susanne Müller et al.
    A collaboration between several pharmaceutical companies provides a unique resource of high-quality chemical probes and associated data from the companies to the academic community.
    1. Neuroscience

    Retrieval practice facilitates memory updating by enhancing and differentiating medial prefrontal cortex representations

    Zhifang Ye et al.
    Retrieval practice strongly engages the medial prefrontal cortex to integrate and differentiate memory representations, resulting in more effective memory updating.
    1. Chromosomes and Gene Expression

    Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

    Ava C Carter et al.
    A long noncoding RNA uses viral mimicry to achieve developmental gene silencing across a chromosome.
    1. Cell Biology

    β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes

    Sophie Schobesberger et al.
    β3-AR signalling via cGMP in cardiomyocytes is regulated via phosphodiesterase 2 and 5 degradation, it is potentially cardioprotective, but dysregulated in heart failure through signal redistribution and higher phosphodiesterase activity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells

    Ananya Mukherjee et al.
    Unique biosensor design and protein-engineering enables direct visualization of the active form of Fyn kinase with high specificity, minimal perturbation and shows cellular signaling to be compartmentalized and pulsatile.
    1. Cell Biology
    2. Immunology and Inflammation

    Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

    Danielle J Clark et al.
    A membrane-associated, supramolecular protein complex with dynamically changing components, the central supramolecular activation cluster, regulates the generation of the T cell effector cytokine IL-2 depending on its composition.

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