1,528 results found
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

    James A Watson, Carolyne M Ndila ... Nicholas J White
    Complete blood count data can increase the accuracy of the diagnosis of severe malaria in children in high transmission settings.
    1. Medicine

    A novel haemocytometric COVID-19 prognostic score developed and validated in an observational multicentre European hospital-based study

    Joachim Linssen, Anthony Ermens ... Andre J van der Ven
    Distinct haemocytometric parameters, including cell activation markers, combined in a prognostic score may support early identification of COVID-19 patients likely to deteriorate and thus may benefit from ICU admission.
    1. Medicine

    Dengue viremia kinetics and effects on platelet count and clinical outcomes: An analysis of 2340 patients from Vietnam

    Nguyen Lam Vuong, Nguyen Than Ha Quyen ... Ronald Geskus
    Higher plasma viremia levels in early dengue and a slower subsequent decline are associated with worse clinical outcomes and provide valuable outcome measures for future therapeutic intervention trials.
    1. Structural Biology and Molecular Biophysics

    Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood

    Nicole Toepfner, Christoph Herold ... Jochen Guck
    The morphology and deformability of all blood cells can be measured continuously and with high throughput directly in whole blood without prior enrichment or separation.
    1. Cell Biology
    2. Developmental Biology

    Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function

    Huanqing Gao, Yiming Zhong ... Guozhi Xiao
    Biochemical and genetic approaches reveal how the focal adhesion protein kindlin-2 controls the liver development and homeostasis by reducing inflammation.
    1. Genetics and Genomics

    Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease

    Surender Rajasekaran, Caleb P Bupp ... André S Bachmann
    Genetic sequencing has led to the increased diagnoses of rare diseases, strategies such as repurposing drugs and global metabolomics offer promise and bring hope to afflicted families.
    1. Stem Cells and Regenerative Medicine

    Thrombopoietin from hepatocytes promotes hematopoietic stem cell regeneration after myeloablation

    Longfei Gao, Matthew Decker ... Lei Ding
    Systemic but not locally produced thrombopoietin promotes hematopoietic stem cell regeneration after myeloablation.
    1. Immunology and Inflammation
    2. Medicine

    Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

    Iago de Castro Silva, Anna Bianchi ... Jashodeep Datta
    A neutrophil-CAF-tumor cell IL-1β/IL-6/STAT-3 signaling axis in the pancreatic tumor microenvironment underlies the association between neutrophil-to-lymphocyte ratio dynamics and pathologic response in patients with pancreatic ductal adenocarcinoma undergoing neoadjuvant therapy.
    1. Microbiology and Infectious Disease

    A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides

    Malik Zohaib Ali, Taru S Dutt ... Mercedes Gonzalez Juarrero
    A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides without showing linezolid associated adverse effects.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    In-silico analysis of myeloid cells across the animal kingdom reveals neutrophil evolution by colony-stimulating factors

    Damilola Pinheiro, Marie-Anne Mawhin ... Kevin J Woollard
    In-silico modeling of gene and protein emergence reveals how colony-stimulating factors contributed to the evolution and functional adaptions observed in mammalian neutrophils.

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