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    1. Neuroscience

    Robotic multi-probe single-actuator inchworm neural microdrive

    Richard D Smith, Ilya Kolb ... Mladen Barbic
    A novel micropositioning approach allows remote-controlled, micrometer-resolution actuation of many densely packed, arbitrarily shaped probes with a device whose size and weight scale much more efficiently with probe count compared to current methods.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia

    D Herbert Opi, Olivia Swann ... J Alexandra Rowe
    Analysis of a large Kenyan dataset may resolve previously conflicting studies by identifying polymorphisms which interact to modify the risk of cerebral malaria.
    1. Cell Biology
    2. Immunology and Inflammation

    Arpin deficiency increases actomyosin contractility and vascular permeability

    Armando Montoya-Garcia, Idaira M Guerrero-Fonseca ... Michael Schnoor
    Arpin regulates actomyosin contractility and endothelial barrier integrity by controlling the activity of the kinases ROCK1 and ZIPK, but not Arp2/3.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration

    Michael RM Harrison, Xidi Feng ... Ching-Ling Lien
    Zebrafish develop cardiac lymphatic vessels along coronary arteries and this vasculature supports scar reduction following severe damage to the myocardium.
    1. Neuroscience

    Predictive models for secondary epilepsy in patients with acute ischemic stroke within one year

    Jinxin Liu, Haoyue He ... Yongbing Deng
    Machine learning models effectively predict the risk of post-stroke epilepsy using extensive clinical data, offering new insights for improving patient management in clinical neurology.
    1. Epidemiology and Global Health
    2. Medicine

    Development and validation of COEWS (COVID-19 Early Warning Score) for hospitalized COVID-19 with laboratory features: A multicontinental retrospective study

    Riku Klén, Ivan A Huespe ... David Gómez-Varela
    The new early warning system, COEWS, will improve the early identification and management of high-risk COVID-19 patients compared to the widely used NEWS2 by using easy-to-obtain clinical parameters that have been externally validated in a diverse multicontinental cohort of patients.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

    Murilo Delgobo, Daniel AGB Mendes ... André Báfica
    Mycobacterium tuberculosis exploits an IFN/IL6/CEBP axis linked to monocyte expansion in humans.
    1. Medicine

    Reprogramming of bone marrow myeloid progenitor cells in patients with severe coronary artery disease

    Marlies P Noz, Siroon Bekkering ... Niels P Riksen
    In patients with coronary artery disease, bone marrow myeloid progenitor cells are reprogrammed towards myeloid skewing and inflammatory activation.
    1. Neuroscience

    State-dependent geometry of population activity in rat auditory cortex

    Dmitry Kobak, Jose L Pardo-Vazquez ... Alfonso Renart
    Representation of sound lateralisation and intensity by neural population in the rat auditory cortex strongly depends on the brain state suggesting that the neural tuning to lateralisation is not hard-wired.