4,611 results found
    1. Neuroscience

    Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity

    Tianyu Tang et al.
    The importance of synchronous Purkinje cell complex spikes for controlling cerebellar output was investigated by simultaneously recording from cerebellar nuclear cells and arrays of Purkinje cells that synapse onto them.
    1. Structural Biology and Molecular Biophysics

    Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

    Baoyu Chen et al.
    The cryo-electron microscopy structure of an assembly of the WAVE Regulatory Complex and its activator, the Rac GTPase, plus complementary biochemistry and biophysics, reveal a novel activation mechanism involving two distinct Rac binding sites.
    1. Ecology

    The golden mimicry complex uses a wide spectrum of defence to deter a community of predators

    Stano Pekár et al.
    A mimetic complex composed of at least 140 species of ants, wasps, spiders, true bugs and treehoppers, all with conspicuous golden bodies, has been discovered.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein

    Ilona Rissanen et al.
    An integrated cryoEM and X-ray crystallography study resolves the structural basis for antibody-mediated targeting of the hantavirus fusion glycoprotein and provides insight into the conformational landscape of the hantavirion surface.
    1. Neuroscience

    Cerebellar climbing fibers encode expected reward size

    Noga Larry et al.
    Electrophysiological recordings in monkeys reveal that cerebellar complex spikes encode future reward size when reward information is first made available, but not during reward delivery or smooth pursuit eye movement.
    1. Neuroscience

    Distinct responses of Purkinje neurons and roles of simple spikes during associative motor learning in larval zebrafish

    Thomas C Harmon et al.
    Discrete classes of cerebellar Purkinje neurons show distinct changes in synaptic and spiking activity during motor learning, with simple spikes playing a shifting role during acquisition, expression, and maintenance of learned responses.
    1. Cell Biology

    Orderly assembly underpinning built-in asymmetry in the yeast centrosome duplication cycle requires cyclin-dependent kinase

    Marco Geymonat et al.
    The polarized orientation of the mitotic spindle in budding yeast arises from spindle pole structural and functional asymmetry subject to cell cycle control.
    1. Neuroscience

    Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis

    Mahdokht Kohansal-Nodehi et al.
    Global phosphoproteomic analysis in nerve terminal during exocytosis reveals 252 uniquely regulated phosphosites, highlighting complex regulation of active zone proteins at multiple sites and the role of specific kinases/phosphatases.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Chromosome organization by one-sided and two-sided loop extrusion

    Edward J Banigan et al.
    Seemingly contradictory findings of single-molecule and in vivo experiments on a major mechanism of chromosome organization are reconciled by computationally investigating mechanisms of loop extrusion that are consistent with both.
    1. Cell Biology

    ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast

    Andrew Murley et al.
    Sites at which mitochondria contact the endoplasmic reticulum co-localize the replication of mitochondria and their DNA to help ensure that DNA is distributed appropriately between the newly formed organelles in cells.

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