7,331 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Sorting of a multi-subunit ubiquitin ligase complex in the endolysosome system

    Xi Yang et al.
    A single transmembrane E3 ligase complex can regulate protein ubiquitination at multiple organelles using interchangeable targeting subunits.
    1. Cell Biology
    2. Computational and Systems Biology

    A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes

    Olga Loza et al.
    Localized feedback on Fa4-Ds1 boundary complexes underlies polarized distribution of Fat4 and Ds1 and gives rise to planar cell polarity.
    1. Structural Biology and Molecular Biophysics

    Hexameric and pentameric complexes of the ExbBD energizer in the Ton system

    Saori Maki-Yonekura et al.
    Crystallography and single particle cryo-EM reveal hexameric and pentameric structures of the ExbBD energizer in the Ton system and oligomeric transition, which provides a unique working mechanism and a new vision of dynamic membrane biology.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Bile salt receptor complex activates a pathogenic type III secretion system

    Peng Li et al.
    Microbial genetics and biophysical analyses provide insight into an evolutionarily conserved bile salt receptor complex used by pathogenic bacteria to sense their environment.
    1. Cell Biology
    2. Computational and Systems Biology

    Bistability of a coupled Aurora B kinase-phosphatase system in cell division

    Anatoly V Zaytsev et al.
    Self-activating Aurora B kinase, opposed by an inhibitory phosphatase, forms spatial phosphorylation patterns during cell division.
    1. Cell Biology
    2. Developmental Biology

    Philosophy of Biology: The analysis of living systems can generate both knowledge and illusions

    Antony M Jose
    By thinking about experimental techniques in terms of six broad approaches – perturbation, visualization, substitution, characterization, reconstitution, and simulation – researchers may be able to generate more reliable inferences.
    1. Neuroscience

    Cell Communication: Studying gap junctions with PARIS

    Daniel R Kick, David J Schulz
    A new genetically encoded system manipulates the pH inside cells to detect whether they are coupled to each other.
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    1. Human Biology and Medicine

    Integrative genomic analysis of the human immune response to influenza vaccination

    Luis M Franco et al.
    By comparing gene expression in people before and after they received the influenza vaccine, researchers were able to identify genes that contribute to differences in individual responses to vaccination.
    1. Cell Biology
    2. Computational and Systems Biology

    Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation

    John M Ankers et al.
    Cell imaging and mathematical modelling show reciprocal cross-regulation between inflammatory signalling and cell cycle timing, which is mediated through functional interactions between NF-B and E2F proteins.

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