A new in vitro approach allows measurement of the efficiency of the early steps of translation initiation on every messenger RNA in yeast simultaneously.

Systems genetics is a powerful approach that links DNA variation to complex clinical and physiological traits through the integration of intermediate phenotypes, such as RNA, protein, and metabolite levels.

A computational framework enables the inference of hydrodynamic continuum models for collective cell migration from live-cell imaging data recorded in zebrafish embryos.

Behavioural states emerge from variability in the complexity of underlying active contraction dynamics in a single-cell, network-shaped forager.

The structure of the Legionella pneumophilaType IV secretion system provides the detailed molecular model of this complex molecular machine required for pathogenesis.

Microbial genetics and biophysical analyses provide insight into an evolutionarily conserved bile salt receptor complex used by pathogenic bacteria to sense their environment.

A single transmembrane E3 ligase complex can regulate protein ubiquitination at multiple organelles using interchangeable targeting subunits.

The structure of a Type IV secretion system provides a framework for understanding assembly of a protein-injection machine.

Genetic mapping reveals widespread, complex genetic effects on protein degradation by the ubiquitin-proteasome system, the primary protein degradation pathway in eukaryotic cells.

The combination of cellular cryo-electron tomography, biochemistry, and mathematical modeling provides the first integrated structural model of the Alphavirus replication organelle.