1,629 results found
    1. Microbiology and Infectious Disease

    NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin

    Ucheor B Choi et al.
    NSF is part of a membrane trafficking quality control system that disassembles both properly formed and off-pathway SNARE complexes, and the disassembly activity may be regulated by complexin.
    1. Structural Biology and Molecular Biophysics

    Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

    Ying Lai et al.
    Building on previous work (Diao et al., 2012), we show that the mechanism by which complexin suppresses spontaneous fusion is distinct from the mechanism by which it synchronizes Ca2+-triggered fusion.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Re-visiting the trans insertion model for complexin clamping

    Shyam S Krishnakumar et al.
    Biochemical experiments provide support for the trans insertion model for clamping in the regulation of neurotransmitter release by complexin.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes

    Eric A Prinslow et al.
    Isothermal titration calorimetry experiments clarify apparently discrepant results described previously and show that N-terminal sequences of complexin bind to SNARE complexes containing C-terminally truncated synaptobrevin when they include the syntaxin-1 juxtamembrane region.
    1. Computational and Systems Biology
    2. Plant Biology

    Topological analysis of multicellular complexity in the plant hypocotyl

    Matthew DB Jackson et al.
    The use of network science to quantify the properties of global cellular organization in the plant hypocotyl identifies higher-order properties and plasticity in epidermal cell patterning.
    1. Neuroscience

    A mechanism for exocytotic arrest by the Complexin C-terminus

    Mazen Makke et al.
    The far C-terminal domain of CpxII interferes with SNARE assembly and thereby arrests tonic exocytosis.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    The accessory helix of complexin functions by stabilizing central helix secondary structure

    Daniel T Radoff et al.
    A deeply conserved feature of complexin's secondary structure underlies its inhibitory function despite poor primary sequence conservation.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex

    Ucheor B Choi et al.
    Complexin can have two conformations when bound to a ternary SNARE complex, one of which induces a conformational change of the SNARE complex at the C-terminus.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Re-examining how complexin inhibits neurotransmitter release

    Thorsten Trimbuch et al.
    Challenging a widespread model, biophysical and electrophysiological experiments suggest a new mechanism whereby complexins inhibit neurotransmitter release through electrostatic repulsion between their accessory helix and the membranes.
    1. Developmental Biology
    2. Evolutionary Biology

    Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity

    Federico Gaiti et al.
    The complex chromatin-based genomic regulatory system controlling developmental gene expression in complex bilaterians predates the evolution of morphological complexity and may have been a prerequisite for the evolution of the first simple multicellular animals.

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