6,937 results found
    1. Ecology
    2. Evolutionary Biology

    Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications

    Susanne RK Zajitschek, Felix Zajitschek ... Shinichi Nakagawa
    Sex differences in trait variability imply that both sexes should be included in biomedical trials, using sex-specific statistical power calculations.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Addressing shortfalls of laboratory HbA1c using a model that incorporates red cell lifespan

    Yongjin Xu, Richard M Bergenstal ... Ramzi A Ajjan
    The person-specific adjusted HbA1c addresses non-glycaemic variation in laboratory HbA1c due to red blood cell lifespan differences, potentially providing a better marker to predict diabetes complications and guide glycaemic management.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    β-hydroxybutyrate accumulates in the rat heart during low-flow ischaemia with implications for functional recovery

    Ross T Lindsay, Sophie Dieckmann ... Andrew J Murray
    β-Hydroxybutyrate accumulates in the perfused rat heart during ischaemia, driven by flux through both HMGCS and SCOT, with implications for functional recovery.
    1. Ecology

    Vessel noise levels drive behavioural responses of humpback whales with implications for whale-watching

    Kate R Sprogis, Simone Videsen, Peter T Madsen
    Controlled exposure experiments reveal that underwater vessel noise level from a motorised vessel is an adequate driver of behavioural disturbance in humpback whales.
    1. Neuroscience

    Cholinergic modulation shifts the response of CA1 pyramidal cells to depolarizing ramps via TRPM4 channels with potential implications for place field firing

    Crescent L Combe, Carol M Upchurch ... Sonia Gasparini
    A nonspecific cation current mediated by TRPM4 channels is a major contributor to the increase in excitability induced by cholinergic modulation in hippocampal CA1 pyramidal neurons, which are thought to play an important role in episodic memory.
    1. Evolutionary Biology

    Computed tomographic analysis of the dental system of three Jurassic ceratopsians and implications for the evolution of tooth replacement pattern and diet in early-diverging ceratopsians

    Jinfeng Hu, Catherine A Forster ... Fenglu Han
    The tooth replacement pattern of early-diverging ceratopsians helps to understand the origin of the specialized dental system of ceratopsids and provides new insights to feeding strategy transition.
    1. Ecology
    2. Epidemiology and Global Health

    Both consumptive and non-consumptive effects of predators impact mosquito populations and have implications for disease transmission

    Marie C Russell, Catherine M Herzog ... Andrew C McCall
    While predators can clearly reduce mosquito populations by consumption, they can also have non-consumptive effects on mosquito body size and oviposition behavior, and these effects on vector traits can influence infectious disease dynamics.
    1. Ecology
    2. Evolutionary Biology

    The African ape-like foot of Ardipithecus ramidus and its implications for the origin of bipedalism

    Thomas Cody Prang
    The most recent common ancestor of humans, chimpanzees, and bonobos possessed a foot adapted to terrestrial quadrupedalism and climbing.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Glutathione binding to the plant AtAtm3 transporter and implications for the conformational coupling of ABC transporters

    Chengcheng Fan, Douglas C Rees
    Multiple cryo-electron microscopy structures of a plant ABC transporter exporting glutathione derivatives captured a closed conformation proposed to enforce the export directionality, while a complex central to the coupling mechanism containing both glutathione and closed nucleotide binding domains remains elusive.
    1. Cell Biology

    Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding

    Manuel Alonso Y Adell, Simona M Migliano ... David Teis
    Quantitative 3D lattice light sheet microscopy of unperturbed cells combined with electron tomography and acute loss of function experiments reveals how dynamic ESCRT-III/Vps4 assemblies succeed in reverse membrane budding on endosomes.

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